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Gene Review:

ZNF195 - zinc finger protein 195

Homo sapiens

Synonyms: HRF1, ZNFP104, Zinc finger protein 195

Hussey, D.J. et al., Pak, B.J. et al., Dao, D. et al., Kjellman, C. et al.

Kjellman, Sjögren, Widegren,

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Disease relevance of ZNF195

One of the HERVs is located downstream of a human Krüppel-related zinc finger protein gene, ZNF195 [1].

High impact information on ZNF195

DNA hypermethylation was not detected with 5" upstream probes for IPL, IMPT1, KvLQT1 and ZNF195 in WTs or WT-associated kidneys [2].
We report the cDNA sequence of the zinc finger gene, ZNF195, which maps to chromosome 11p15 [3].
Northern analysis shows expression of ZNF195 in adult heart, brain, placenta, skeletal muscle, and pancreas with a predominant transcript size of 4.3 kb [3].

Biological context of ZNF195

5. ZNF195 contains an N-terminal KRAB domain and 14 tandemly repeated Krüppel type zinc finger motifs at its C-terminus [3].

Analytical, diagnostic and therapeutic context of ZNF195

DNA sequencing and sequence analysis revealed that HRF-1 may represent an alternatively spliced or tissue-specific form of the Kruppel family zinc finger protein znfp104 gene [4].

References

HERV-F, a new group of human endogenous retrovirus sequences. Kjellman, C., Sjögren, H.O., Widegren, B. J. Gen. Virol. (1999) [Pubmed]
Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. Dao, D., Walsh, C.P., Yuan, L., Gorelov, D., Feng, L., Hensle, T., Nisen, P., Yamashiro, D.J., Bestor, T.H., Tycko, B. Hum. Mol. Genet. (1999) [Pubmed]
Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5. Hussey, D.J., Parker, N.J., Hussey, N.D., Little, P.F., Dobrovic, A. Genomics (1997) [Pubmed]
Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells. Pak, B.J., Park, H., Chang, E.R., Pang, S.C., Graham, C.H. Placenta (1998) [Pubmed]

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