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Gene Review:

LRRK1 - leucine-rich repeat kinase 1

Homo sapiens

Synonyms: FLJ23119, KIAA1790, Leucine-rich repeat serine/threonine-protein kinase 1, RIPK6, Roco1

Adams, J.R. et al., Clark, L.N. et al., Korr, D. et al., Biskup, S. et al.

Clark, Wang, Karlins, Saito, Mejia-Santana, Harris, Louis, Cote, Andrews, Fahn, Waters, Ford, Frucht, Ottman, Marder,

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Disease relevance of LRRK1

Ultimately, the results presented for LRRK1 may contribute to the elucidation of LRRK2's role in the pathogenesis of Parkinson's disease [1].
Multiple mutations in the gene for the leucine-rich repeat kinase (LRRK2) cause autosomal dominant late-onset parkinsonism (PARK8) [2].

Biological context of LRRK1

OBJECTIVE: To evaluate the frequency of leucine-rich repeat kinase gene (LRRK2) mutations and single nucleotide polymorphisms (SNPs) in early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD) [3].

Analytical, diagnostic and therapeutic context of LRRK1

We describe here the positron emission tomography (PET) findings in clinically affected and asymptomatic, high-risk members of two autosomal dominantly inherited Parkinson's disease kindreds with recently described mutations at the PARK8 locus, in a novel gene encoding a leucine-rich repeat kinase (LRRK2) [4].

References

LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. Korr, D., Toschi, L., Donner, P., Pohlenz, H.D., Kreft, B., Weiss, B. Cell. Signal. (2006) [Pubmed]
Common variants of LRRK2 are not associated with sporadic Parkinson's disease. Biskup, S., Mueller, J.C., Sharma, M., Lichtner, P., Zimprich, A., Berg, D., Wüllner, U., Illig, T., Meitinger, T., Gasser, T. Ann. Neurol. (2005) [Pubmed]
Frequency of LRRK2 mutations in early- and late-onset Parkinson disease. Clark, L.N., Wang, Y., Karlins, E., Saito, L., Mejia-Santana, H., Harris, J., Louis, E.D., Cote, L.J., Andrews, H., Fahn, S., Waters, C., Ford, B., Frucht, S., Ottman, R., Marder, K. Neurology (2006) [Pubmed]
PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation. Adams, J.R., van Netten, H., Schulzer, M., Mak, E., Mckenzie, J., Strongosky, A., Sossi, V., Ruth, T.J., Lee, C.S., Farrer, M., Gasser, T., Uitti, R.J., Calne, D.B., Wszolek, Z.K., Stoessl, A.J. Brain (2005) [Pubmed]

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