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Gene Review:

Pum1 - pumilio RNA-binding family member 1

Mus musculus

Synonyms: AA517475, Kiaa0099, Pumilio homolog 1, Pumm, mKIAA0099

Spassov, D.S. et al., Yamamoto, H. et al.

Yamamoto, Imai, Takamatsu, Kamegaya, Hara, Shimada, Yamamoto, Shen, Hagino, Kobayashi, Ide, Sora, Koga, Ikedaa,

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High impact information on Pum1

Several clones were chosen as positive candidates for methamphetamine-induced changes; however, only Per2 and mKIAA0099 genes showed a significantly increased expression (P < .05) [1].
In a more heterogeneous population of HSC (Lin(-)Sca-1(+)) and in progenitors (Lin(-)Sca-1(-) cells) Pum1 is not transcribed, whereas Pum2 expression is significantly down-regulated [2].

Anatomical context of Pum1

During blood cell development Pum1 and Pum2 exhibit differential expression in cell populations enriched for HSC and progenitors [2].
Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors [2].

References

Changes in expression of the mouse homologues of KIAA genes after subchronic methamphetamine treatment. Yamamoto, H., Imai, K., Takamatsu, Y., Kamegaya, E., Hara, Y., Shimada, K., Yamamoto, T., Shen, H.W., Hagino, Y., Kobayashi, H., Ide, S., Sora, I., Koga, H., Ikedaa, K. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors. Spassov, D.S., Jurecic, R. Blood Cells Mol. Dis. (2003) [Pubmed]

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