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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DEFB126  -  defensin, beta 126

Homo sapiens

Synonyms: Beta-defensin 126, Beta-defensin 26, C20orf8, DEFB-26, DEFB26, ...
 
 
 
 
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High impact information on DEFB126

  • Sperm treated with neuraminidase to remove sialic acid on DEFB126 before fixation were shown to still possess DEFB126, but lacked the sialic acid component of the glycoprotein [1].
  • Experiments using different sperm plasma membrane protein-specific Igs showed that recognition did not occur when DEFB126 was present, but following capacitation these Igs readily recognized the exposed sperm membrane [1].
 

Associations of DEFB126 with chemical compounds

  • Our data suggest that DEFB126 protects the entire primate sperm surface from immune recognition and that the sialic acid moieties are responsible for the cloaking characteristic of this unique glycoprotein [1].
 

Analytical, diagnostic and therapeutic context of DEFB126

  • Sera from rabbits that were immunized with sperm washed more rigorously using Percoll gradients showed an increase in the number and intensity of proteins recognized on whole sperm Western blots, although DEFB126 was still the major immune response [1].

References

  1. Beta-defensin 126 on the cell surface protects sperm from immunorecognition and binding of anti-sperm antibodies. Yudin, A.I., Generao, S.E., Tollner, T.L., Treece, C.A., Overstreet, J.W., Cherr, G.N. Biol. Reprod. (2005) [Pubmed]
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