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Gene Review

SGS3  -  protein SUPPRESSOR OF GENE SILENCING 3

Arabidopsis thaliana

Synonyms: ATSGS3, MQM1.17, MQM1_17, SUPPRESSOR OF GENE SILENCING 3
 
 
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Disease relevance of SGS3

  • Geminivirus VIGS of endogenous genes requires SGS2/SDE1 and SGS3 and defines a new branch in the genetic pathway for silencing in plants [1].
  • In populations of first generation (T1) A. thaliana plants transformed with a beta-glucuronidase (GUS) gene (uidA) driven by the 35S cauliflower mosaic virus promoter (p35S), the incidence of highly expressing transformants shifted from 20% in wild type background to 100% in sgs2 and sgs3 backgrounds [2].
 

High impact information on SGS3

  • Here, we report the isolation of sgs2 and sgs3 Arabidopsis mutants impaired in PTGS [3].
  • A DNA VIGS vector derived from CaLCuV, which silenced chlorata42 (ChlI) needed for chlorophyll formation, was used to test endogenous gene silencing responses in suppressor of gene silencing (sgs)1, sgs2, sgs3, and Argonaute (ago)1 mutants defective in sense transgene-mediated post-transcriptional silencing (S-PTGS) [1].
  • By a detailed analysis of the sequence of SGS3 we have defined three new protein domains: the XH domain, the XS domain and the zf-XS domain, that are shared with a large family of uncharacterised plant proteins [4].
  • A bioinformatics approach has implicated a new family of plant proteins related to SGS3 as potential candidates for PTGS related functions [4].
 

Biological context of SGS3

 

Other interactions of SGS3

  • The RDR6-SGS3-AGO7 pathway was previously identified as regulating the plant vegetative phase change [5].

References

  1. Geminivirus VIGS of endogenous genes requires SGS2/SDE1 and SGS3 and defines a new branch in the genetic pathway for silencing in plants. Muangsan, N., Beclin, C., Vaucheret, H., Robertson, D. Plant J. (2004) [Pubmed]
  2. Stable high-level transgene expression in Arabidopsis thaliana using gene silencing mutants and matrix attachment regions. Butaye, K.M., Goderis, I.J., Wouters, P.F., Pues, J.M., Delauré, S.L., Broekaert, W.F., Depicker, A., Cammue, B.P., De Bolle, M.F. Plant J. (2004) [Pubmed]
  3. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Mourrain, P., Béclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.B., Jouette, D., Lacombe, A.M., Nikic, S., Picault, N., Rémoué, K., Sanial, M., Vo, T.A., Vaucheret, H. Cell (2000) [Pubmed]
  4. The SGS3 protein involved in PTGS finds a family. Bateman, A. BMC Bioinformatics (2002) [Pubmed]
  5. Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis. Xu, L., Yang, L., Pi, L., Liu, Q., Ling, Q., Wang, H., Poethig, R.S., Huang, H. Plant Cell Physiol. (2006) [Pubmed]
 
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