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AT5G42740  -  glucose-6-phosphate isomerase

Arabidopsis thaliana

Synonyms: MJB21.12, MJB21_12
 
 
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High impact information on AT5G42740

 

Biological context of AT5G42740

  • The nucleotide sequence of PgiC1-a which encodes a cytosolic isozymes of phosphoglucose isomerase (PGIC; EC 5.3.1.9) in Clarkia lewisii, a wildflower native to California, is described and compared to the previously published sequence of the duplicate PgiC2-a from the same genome [6].
  • N-bromoacetylethanolamine phosphate inactivated irreversibly the activity of wild-type phosphoglucose isomerase; however, His311 --> Ala became resistant to this inhibitor, indicating that His311 is located in the active site and is responsible for the inactivation of the enzyme by this active site-directed inhibitor [7].
 

Associations of AT5G42740 with chemical compounds

References

  1. DNA polymorphism in active gene and pseudogene of the cytosolic phosphoglucose isomerase (PgiC) loci in Arabidopsis halleri ssp. gemmifera. Kawabe, A., Miyashita, N.T. Mol. Biol. Evol. (2003) [Pubmed]
  2. Microarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-phosphate, iron, and sulfate metabolism. Wang, R., Okamoto, M., Xing, X., Crawford, N.M. Plant Physiol. (2003) [Pubmed]
  3. The 5' leader of plant PgiC has an intron: the leader shows both the loss and maintenance of constraints compared with introns and exons in the coding region. Gottlieb, L.D., Ford, V.S. Mol. Biol. Evol. (2002) [Pubmed]
  4. Mutation of Arabidopsis plastid phosphoglucose isomerase affects leaf starch synthesis and floral initiation. Yu, T.S., Lue, W.L., Wang, S.M., Chen, J. Plant Physiol. (2000) [Pubmed]
  5. The molecular basis of quantitative genetic variation in central and secondary metabolism in Arabidopsis. Mitchell-Olds, T., Pedersen, D. Genetics (1998) [Pubmed]
  6. Molecular characterization of duplicate cytosolic phosphoglucose isomerase genes in Clarkia and comparison to the single gene in Arabidopsis. Thomas, B.R., Ford, V.S., Pichersky, E., Gottlieb, L.D. Genetics (1993) [Pubmed]
  7. Probing the location and function of the conserved histidine residue of phosphoglucose isomerase by using an active site directed inhibitor N-bromoacetylethanolamine phosphate. Meng, M., Chane, T.L., Sun, Y.J., Hsiao, C.D. Protein Sci. (1999) [Pubmed]
 
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