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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

WDR83  -  WD repeat domain 83

Homo sapiens

Synonyms: MAPK organizer 1, MORG1, Mitogen-activated protein kinase organizer 1, WD repeat domain-containing protein 83
 
 
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Disease relevance of MORG1

  • In this context, depressed mutants of Enterobacter spp., Citro. freundii and Ps. aeruginosa could be of primary concern although those of Ser. marcescens, Prov. stuartii and Morg. morganii often exhibited equally high resistance levels to older beta-lactams [1].
 

High impact information on MORG1

  • We identified a novel WD-repeat protein, recently designated Morg1 (MAPK organizer 1), by screening a cDNA library with yeast two-hybrid assays [2].
  • Finally, HIF-mediated reporter gene activity is decreased by Morg1 and reduced to basal levels when Morg1 is co-expressed with PHD3 [2].
  • For example, cefoxitin was a powerful inducer in Ent. cloacae, Citro. freundii and one strain of Ps. aeruginosa; similarly cefazolin and cefuroxime were good beta-lactamase inducers in Ser. marcescens and Morg. morganii [1].

References

  1. Inducible type I beta-lactamases of gram-negative bacteria and resistance to beta-lactam antibiotics. Curtis, N.A., Eisenstadt, R.L., Rudd, C., White, A.J. J. Antimicrob. Chemother. (1986) [Pubmed]
  2. The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3). Hopfer, U., Hopfer, H., Jablonski, K., Stahl, R.A., Wolf, G. J. Biol. Chem. (2006) [Pubmed]
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