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Gene Review:

CDC14A - cell division cycle 14A

Homo sapiens

Synonyms: CDC14 cell division cycle 14 homolog A, Cdc14A1, Cdc14A2, Dual specificity protein phosphatase CDC14A, cdc14, ...

Wong, A.K. et al., Jiménez, J. et al.

Wong, Chen, Lian, Ha, Petersen, Laity, Carillo, Emerson, Heichman, Gupte, Tavtigian, Teng,

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Disease relevance of CDC14A

By radiation hybrid mapping, we localized CDC14A to chromosome band 1p21, a region that has been shown to exhibit loss of heterozygosity in highly differentiated breast carcinoma and malignant mesothelioma [1].

High impact information on CDC14A

Loss of expression of the wildtype allele in the same breast cell line supports the possibility that CDC14A may be a tumor suppressor gene that is targeted for inactivation during tumorigenesis [1].
Overexpression of the human CDC14A and CDC14B genes complemented, although very poorly, S. cerevisiae cdc15-lyt1 and dbf2-2 mutants, suggesting a conserved function of these genes throughout phylogeny [2].

References

Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. Wong, A.K., Chen, Y., Lian, L., Ha, P.C., Petersen, K., Laity, K., Carillo, A., Emerson, M., Heichman, K., Gupte, J., Tavtigian, S.V., Teng, D.H. Genomics (1999) [Pubmed]
A single-copy suppressor of the Saccharomyces cerevisae late-mitotic mutants cdc15 and dbf2 is encoded by the Candida albicans CDC14 gene. Jiménez, J., Cid, V.J., Nombela, C., Sánchez, M. Yeast (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CDC14A	Bos taurus
cdc-14	Caenorhabditis elegans
CDC14A	Canis lupus familiaris
cdc14ab	Danio rerio
CDC14A	Gallus gallus
CDC14A	Macaca mulatta
Cdc14a	Mus musculus
CDC14A	Pan troglodytes
Cdc14a	Rattus norvegicus
cdc14a	Xenopus (Silurana) tropicalis

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