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Gene Review

CBLN1  -  cerebellin 1 precursor

Homo sapiens

Synonyms: Cerebellin-1, Precerebellin
 
 
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Disease relevance of CBLN1

 

High impact information on CBLN1

  • Notably, the phenotype of cbln1-null mice mimics loss-of-function mutations in the orphan glutamate receptor, GluR delta2, a gene selectively expressed in Purkinje neurons [2].
  • Therefore, cerebellin is not liberated from precerebellin by the classical dibasic amino acid proteolytic-cleavage mechanism seen in many neuropeptide precursors [3].
  • The amino terminus of precerebellin contains three possible N-linked glycosylation sites [3].
  • The gC1q modules are also found in a variety of noncomplement proteins, such as type VIII and X collagens, precerebellin, hibernation protein, multimerin, Acrp-30, and saccular collagen [4].
  • For example, genes encoding a precerebellin-like protein and complement component C3 were downregulated in R relative to C (R<C) in two microarray studies, and hemoglobins alpha and beta were R>C in all three studies [5].
 

Biological context of CBLN1

  • The cerebellum-specific hexadecapeptide, cerebellin, is derived from a larger precursor, precerebellin, that has sequence homology to the complement component C1qB [6].
 

Anatomical context of CBLN1

 

Other interactions of CBLN1

References

  1. A precerebellin-like protein is part of the acute phase response in rainbow trout, Oncorhynchus mykiss. Gerwick, L., Reynolds, W.S., Bayne, C.J. Dev. Comp. Immunol. (2000) [Pubmed]
  2. Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Hirai, H., Pang, Z., Bao, D., Miyazaki, T., Li, L., Miura, E., Parris, J., Rong, Y., Watanabe, M., Yuzaki, M., Morgan, J.I. Nat. Neurosci. (2005) [Pubmed]
  3. Precerebellin is a cerebellum-specific protein with similarity to the globular domain of complement C1q B chain. Urade, Y., Oberdick, J., Molinar-Rode, R., Morgan, J.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. A recombinant homotrimer, composed of the alpha helical neck region of human surfactant protein D and C1q B chain globular domain, is an inhibitor of the classical complement pathway. Kishore, U., Strong, P., Perdikoulis, M.V., Reid, K.B. J. Immunol. (2001) [Pubmed]
  5. Multiple microarray platforms utilized for hepatic gene expression profiling of GH transgenic coho salmon with and without ration restriction. Rise, M.L., Douglas, S.E., Sakhrani, D., Williams, J., Ewart, K.V., Rise, M., Davidson, W.S., Koop, B.F., Devlin, R.H. J. Mol. Endocrinol. (2006) [Pubmed]
  6. Genomic structure and mapping of precerebellin and a precerebellin-related gene. Kavety, B., Jenkins, N.A., Fletcher, C.F., Copeland, N.G., Morgan, J.I. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  7. Cerebellin in the rat adrenal gland: gene expression and effects of CER and [des-Ser1]CER on the secretion and growth of cultured adrenocortical cells. Rucinski, M., Albertin, G., Spinazzi, R., Ziolkowska, A., Nussdorfer, G.G., Malendowicz, L.K. Int. J. Mol. Med. (2005) [Pubmed]
  8. The acute phase response and innate immunity of fish. Bayne, C.J., Gerwick, L. Dev. Comp. Immunol. (2001) [Pubmed]
  9. Immune-relevant (including acute phase) genes identified in the livers of rainbow trout, Oncorhynchus mykiss, by means of suppression subtractive hybridization. Bayne, C.J., Gerwick, L., Fujiki, K., Nakao, M., Yano, T. Dev. Comp. Immunol. (2001) [Pubmed]
 
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