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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IL1RL2  -  interleukin 1 receptor-like 2

Homo sapiens

Synonyms: IL-1Rrp2, IL-36 receptor, IL-36R, IL1R-rp2, IL1RRP2, ...
 
 
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Disease relevance of IL1RL2

  • In lesional psoriasis skin, characterized by chronic cutaneous inflammation, the mRNA expression of both IL-1 ligands as well as IL-1Rrp2 are increased relative to normal healthy skin [1].
 

High impact information on IL1RL2

  • In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection [2].
  • Human synovial fibroblasts (hSFs) and human articular chondrocytes (hACs) expressed the IL-1F8 receptor (IL-1Rrp2) and produced pro-inflammatory mediators in response to recombinant IL-1F8 [3].

References

  1. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. Debets, R., Timans, J.C., Homey, B., Zurawski, S., Sana, T.R., Lo, S., Wagner, J., Edwards, G., Clifford, T., Menon, S., Bazan, J.F., Kastelein, R.A. J. Immunol. (2001) [Pubmed]
  2. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. Towne, J.E., Garka, K.E., Renshaw, B.R., Virca, G.D., Sims, J.E. J. Biol. Chem. (2004) [Pubmed]
  3. The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Magne, D., Palmer, G., Barton, J.L., Mézin, F., Talabot-Ayer, D., Bas, S., Duffy, T., Noger, M., Guerne, P.A., Nicklin, M.J., Gabay, C. Arthritis Res. Ther. (2006) [Pubmed]
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