Gene Review:
iniA - isoniazid inductible protein IniA
Mycobacterium tuberculosis H37Rv
- The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol. Colangeli, R., Helb, D., Sridharan, S., Sun, J., Varma-Basil, M., Hazbón, M.H., Harbacheuski, R., Megjugorac, N.J., Jacobs, W.R., Holzenburg, A., Sacchettini, J.C., Alland, D. Mol. Microbiol. (2005)
- Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DECAL): the effect of isoniazid on gene expression in Mycobacterium tuberculosis. Alland, D., Kramnik, I., Weisbrod, T.R., Otsubo, L., Cerny, R., Miller, L.P., Jacobs, W.R., Bloom, B.R. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis. Ramaswamy, S.V., Amin, A.G., Göksel, S., Stager, C.E., Dou, S.J., El Sahly, H., Moghazeh, S.L., Kreiswirth, B.N., Musser, J.M. Antimicrob. Agents Chemother. (2000)
- Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition. Alland, D., Steyn, A.J., Weisbrod, T., Aldrich, K., Jacobs, W.R. J. Bacteriol. (2000)