Disease relevance of Matched-Pair Analysis

• In the current study, 22 breast tumors with deleterious BRCA1 mutations were analyzed for Fhit expression by immunohistochemistry in a case-control matched pair analysis [1].
• A paired comparison of cream and ointment-based dithranol in short contact treatment of psoriasis [2].
• Data were reviewed on the beneficial responses and adverse reactions among 2,849 patients in 14 paired-comparison studies with eight unoccluded topical corticosteroids in six steroid-responsive dermatoses [3].
• Double-masked, paired-comparison clinical study of ketorolac tromethamine 0.5% ophthalmic solution compared with placebo eyedrops in the treatment of seasonal allergic conjunctivitis [4].
• Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses [5].

Psychiatry related information on Matched-Pair Analysis

• Similar differences in favor of halazepam were observed at the same time points on paired comparison of percent improvement from baseline in scores for physician's global assessment of psychopathology and the Hamilton Anxiety Scale [6].

High impact information on Matched-Pair Analysis

• In contrast, when Jv was increased, paired comparison of Ralb and RDX in the same AVR revealed a difference, 1.58 +/- 0.06 vs 1.72 +/- 0.08, respectively (P less than 0.01) [7].
• In crude matched-pair analyses, baseline concentrations of tPA antigen were higher in cases than controls (p = 0.03) and strongly associated with risk of future MI [8].
• Illness-recovery correlations using area under the curve for GH secretion during sleep were highly significant, whereas paired comparisons showed no significant differences [9].
• A matched-pair analysis of NF-kappa B expression was performed in cases with vascular involvement and increased tumor vascularity versus matched controls lacking these factors [10].
• First-line high-dose chemotherapy compared with standard-dose PEB/VIP chemotherapy in patients with advanced germ cell tumors: A multivariate and matched-pair analysis [11].

Chemical compound and disease context of Matched-Pair Analysis

• We evaluated 148 patients with allergic conjunctivitis in a double-masked, paired comparison clinical trial comparing ketorolac 0.5% ophthalmic solution with vehicle [12].
• In a double-blind, paired-comparison study of the effectiveness of corticosteroid creams used under occlusion for the treatment of moderate to severe psoriasis, a new drug, halcinonide cream, was superior to betamethasone valerate cream, a steroid widely and effectively used for the treatment of psoriasis [13].
• The mean values and regression coefficients of reciprocal sCr, CCr, urinary creatinine excretion (uCr x V), proteinuria, BW, blood pressure (BP), serum cholesterol (sChol), and serum triglycerides (sTG) versus time were analyzed 12 months before and after institution of MMF by a paired-comparison t test [14].
• In a bilateral paired comparison study 39 patients with plaque psoriasis completed a 4 week study using hydrocolloid dressing alone, twice daily Betamethasone propionate cream alone, or both therapies combined and applied every 7 days [15].
• Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis [16].

Biological context of Matched-Pair Analysis

• According to a matched-pair analysis, pancreas graft survival for SPK recipients at 6 months was 87% for FK506 versus 70% for cyclosporine recipients (P = 0.04); for PTA recipients, 84% versus 66% (P = n.s.); and for PAK recipients, 80% versus 14% (P = 0.11) [17].
• Analysis of maximum expiratory flow at functional residual capacity (V'maxFRC) before and after albuterol administration was performed using a t-test for paired comparisons [18].
• The underlying metric was examined with a paired comparison task while measuring event-related potentials (ERP) for subjects classified as 'career decided' and 'career undecided'. Stimuli for comparison were presented either sequentially or simultaneously [19].

Anatomical context of Matched-Pair Analysis

• Quantitative assessment of postsurgical breakdown of the blood-aqueous barrier following administration of 0.5% ketorolac tromethamine solution. A double-masked, paired comparison with vehicle-placebo solution study [20].
• The serum gastrin concentrations were determined and found by paired comparison to be statistically significantly (p less than 0.05) higher in the peripheral than in the renal vein [21].
• A preference for iohexol after injection into the external carotid artery in a paired comparison was established in 84.2 per cent of the patients [22].
• Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition memory [23].
• RESULTS: Paired comparisons between matched subjects showed that SS have greater body fat percentage than TS (Delta = 1.40%, p = 0.04) [24].

Associations of Matched-Pair Analysis with chemical compounds

• In paired comparisons of 100/cystatin C with iothalamate clearance at each examination, the two measures were numerically similar [25].
• During chronic administration of 200 mg ketoconazole daily, decrements of plasma testosterone 2-4 h after drug administration were minimal and documented only by paired comparisons within subjects but not by unpaired tests between normal men and men receiving drug [26].
• On paired comparisons, the hormone responses to MTC were lower (P less than 0.05) during the infusion of high dose DA (PRL, 2286 +/- 495% vs. 891 +/- 328%; TSH, 100 +/- 43% vs. 60 +/- 15%), but were not changed when MTC was given during the low and medium doses of DA [27].
• Paired comparison of the results from each kit indicated that the NovoClone Target assay showed significantly lower diagnostic sensitivity (P less than 0.05) than did the Tandem Icon II or Abbott TestPack, both for urine and for serum samples [28].
• Then a matched-pair analysis of patients treated without androgen deprivation was implemented [29].

Gene context of Matched-Pair Analysis

• Paired comparison revealed a highly significant negative correlation between IFN-gamma and IgG (P=0.016), IgG1 (P<0.001) and IgG3 (P=0. 007) antibodies [30].
• A matched pair analysis of normal and cancerous endometrial tissue confirmed the significance of the DPP III activity increase in the transformed tissue (n = 7, P = 0.022) [31].
• Paired comparisons demonstrated a sexually dimorphic effect of rhGH therapy on the CYP3A activity [32].
• The paired comparisons method of identifying developmental discrepancies with the ITPA [33].
• Results of matched-pair analyses were calculated and revealed a significant with-in pair discordance, when comparing children with NF-1 and their siblings and when comparing children with NF-1 and their biological parents (in families with a sporadic, non-familial NF-1 child) [34].

Analytical, diagnostic and therapeutic context of Matched-Pair Analysis

• In a double-blind, paired-comparison, placebo-controlled study, the diet of 10 healthy female volunteers, aged 20-22 yr, was supplemented for a period of 7 wk with 7.5 g sodium propionate daily in capsule form, while the diet of the 10 control group members was supplemented with dibasic calcium phosphate in identical capsules as placebo [35].
• This was a double-masked, randomized, paired comparison with vehicle trial of a topically administered prostaglandin (PG)E2 in healthy human volunteers [36].
• Ten normal listeners and ten listeners with high-frequency sensorineural hearing loss were given a paired-comparison task designed to elicit relative quality preferences among hearing aids when male speech, female speech, and music were processed by five different instruments [37].

References