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MeSH Review

Paraneoplastic Syndromes, Nervous System

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Disease relevance of Paraneoplastic Syndromes, Nervous System


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Chemical compound and disease context of Paraneoplastic Syndromes, Nervous System


Anatomical context of Paraneoplastic Syndromes, Nervous System


Gene context of Paraneoplastic Syndromes, Nervous System

  • Since anti-Hu RRM domain antibodies are associated with an anti-tumor effect and paraneoplastic encephalomyelitis, we tested sera from Hu syndrome patients with the RRMs of DEF-3(g16/NY-LU-12) and LUCA15 [15].
  • The expression of mRNA for the neuronal antigen HuD (Elavl4) associated with paraneoplastic encephalomyelitis and sensory neuronopathy was evaluated in the developing and adult rat nervous system [16].
  • The serum of all patients with anti-Hu-associated paraneoplastic encephalomyelitis and sensory neuronopathy react with HuD and Hel-N1, but the reactivity with HuC is unknown [17].
  • We studied the nervous systems and tumors of five patients with anti-Hu-positive paraneoplastic encephalomyelitis/sensory neuronopathy (PEM/PSN) to determine if the autoantibody found in the serum and CSF was also present in those tissues [18].
  • Using immunohistochemistry, we studied the IgG subclass distribution of the anti-Hu antibody in serum, nervous system, and tumor of patients with anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuropathy (PEM/PSN) [19].


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  6. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J.B., Furneaux, H.M. Cell (1991) [Pubmed]
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  15. DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC. Drabkin, H.A., West, J.D., Hotfilder, M., Heng, Y.M., Erickson, P., Calvo, R., Dalmau, J., Gemmill, R.M., Sablitzky, F. Oncogene (1999) [Pubmed]
  16. Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system development. Clayton, G.H., Perez, G.M., Smith, R.L., Owens, G.C. Brain Res. Dev. Brain Res. (1998) [Pubmed]
  17. Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Manley, G.T., Smitt, P.S., Dalmau, J., Posner, J.B. Ann. Neurol. (1995) [Pubmed]
  18. Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuronopathy. Dalmau, J., Furneaux, H.M., Rosenblum, M.K., Graus, F., Posner, J.B. Neurology (1991) [Pubmed]
  19. Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Jean, W.C., Dalmau, J., Ho, A., Posner, J.B. Neurology (1994) [Pubmed]
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