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MeSH Review

Prenatal Injuries

 
 
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High impact information on Prenatal Injuries

  • INTERPRETATION: Prospective treatment with this regimen can favorably modify the early neonatal course of severe NKH but does not prevent the poor long-term outcome, suggesting glycine-induced prenatal injury and/or ongoing postnatal damage [1].
  • A false-negative MRS finding (normal lactate/choline but abnormal outcome) was seen in a patient who had an apparent prenatal injury [2].

References

  1. Treatment from birth of nonketotic hyperglycinemia due to a novel GLDC mutation. Korman, S.H., Wexler, I.D., Gutman, A., Rolland, M.O., Kanno, J., Kure, S. Ann. Neurol. (2006) [Pubmed]
  2. Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. Barkovich, A.J., Baranski, K., Vigneron, D., Partridge, J.C., Hallam, D.K., Hajnal, B.L., Ferriero, D.M. AJNR. American journal of neuroradiology. (1999) [Pubmed]
 
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