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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease.

The frequency of various allele types of the class I Major Histocompatibility Complex (MHC) genes HLA-A and HLA-B were compared between pathologically confirmed groups of late and early-onset Alzheimer's disease (AD) and a control group. DNA was extracted from frozen brain tissue and the highly polymorphic second and third exons of the HLA-A and HLA-B genes were independently PCR amplified using specific primers. Individual allele types were identified using sequence-specific oligonucleotide probes. The results showed that the main frequency differences occurred between the late-onset AD and the control group however none of these reached statistical significance.[1]

References

  1. Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease. Middleton, D., Mawhinney, H., Curran, M.D., Edwardson, J.A., Perry, R., McKeith, I., Morris, C., Ince, P.G., Neill, D. Neurosci. Lett. (1999) [Pubmed]
 
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