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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5).

We screened for genes whose expression is significantly up- or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor-5 (FGF-5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve. Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family.[1]

References

  1. Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5). Scarlato, M., Xu, T., Bannerman, P., Beesley, J., Reddy, U.R., Rostami, A., Scherer, S.S., Pleasure, D. J. Neurosci. Res. (2001) [Pubmed]
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