Amplifying mechanisms of lymphomagenesis.
Mice doubly deficient for either XRCC4 or DNA ligase IV and p53 invariably develop lymphomas bearing characteristic chromosome translocations with gene amplification. A recent study highlights the importance of nonclassical end joining mechanisms in the formation of these oncogenic DNA rearrangements.[1]References
- Amplifying mechanisms of lymphomagenesis. Roth, D.B. Mol. Cell (2002) [Pubmed]
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