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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Amplifying mechanisms of lymphomagenesis.

Mice doubly deficient for either XRCC4 or DNA ligase IV and p53 invariably develop lymphomas bearing characteristic chromosome translocations with gene amplification. A recent study highlights the importance of nonclassical end joining mechanisms in the formation of these oncogenic DNA rearrangements.[1]

References

  1. Amplifying mechanisms of lymphomagenesis. Roth, D.B. Mol. Cell (2002) [Pubmed]
 
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