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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.

Pharmacologic inhibition of indoleamine 2,3-dioxygenase ( IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal-fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.[1]

References

  1. Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy. Mellor, A.L., Chandler, P., Lee, G.K., Johnson, T., Keskin, D.B., Lee, J., Munn, D.H. J. Reprod. Immunol. (2002) [Pubmed]
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