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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Identification of new partners of the epithelial sodium channel alpha subunit.

A fine regulation of the amiloride-sensitive Epithelial Sodium Channel (ENaC), made of alpha, beta and gamma subunits, is crucial for maintenance of Na+ balance and blood pressure. Both beta- and gamma-ENaC participate in negative regulation by interacting with Nedd4-2, an E3 ubiquitin-ligase. Disruption of this interaction results in increased ENaC activity (Liddle syndrome). By two-hybrid screenings, we identified new potential partners of alpha-ENaC: WWP1 ( E3 ubiquitin-ligase protein), UBC9 and TSG101 ( E2 ubiquitin/SUMO-conjugating enzymes) and confirmed these interactions in GST pull-down assays. All these partners are implicated in protein trafficking and could be involved in the regulation of ENaC activity.[1]

References

  1. Identification of new partners of the epithelial sodium channel alpha subunit. Malbert-Colas, L., Nicolas, G., Galand, C., Lecomte, M.C., Dhermy, D. C. R. Biol. (2003) [Pubmed]
 
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