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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.[1]


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