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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

VDUP1 is required for the development of natural killer cells.

Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.[1]

References

  1. VDUP1 is required for the development of natural killer cells. Lee, K.N., Kang, H.S., Jeon, J.H., Kim, E.M., Yoon, S.R., Song, H., Lyu, C.Y., Piao, Z.H., Kim, S.U., Han, Y.H., Song, S.S., Lee, Y.H., Song, K.S., Kim, Y.M., Yu, D.Y., Choi, I. Immunity (2005) [Pubmed]
 
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