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Txnip  -  thioredoxin interacting protein

Mus musculus

Synonyms: 1200008J08Rik, AA682105, Hyplip1, THIF, Tbp-2, ...
 
 
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Disease relevance of Txnip

 

High impact information on Txnip

 

Biological context of Txnip

 

Anatomical context of Txnip

 

Associations of Txnip with chemical compounds

  • Hepatic ratios of reduced:oxidized glutathione, established regulators of gluconeogenic/glycolytic/lipogenic enzymes, were elevated 30% in HcB-19 mice, suggesting a loss of Txnip-enhanced sulfhydryl reduction [8].
  • Liver CE content was elevated despite lower cholesterol fractional synthesis rates (16 vs. 31%/d in Txnip(-/-) and WT mice, respectively) [9].
  • Vitamin D3 up-regulated protein 1 (VDUP1) is a stress-response gene that is up-regulated by 1,25(OH)2D3 in many cells [7].
  • Stable overexpression of TXNIP in MES-13 cells increases glucose and glucosamine-mediated ECM gene expression and oxidative stress [11].
  • While available thioredoxin is not changed in Txnip-null mice, the effects of Txnip on glucose homeostasis are abolished by a single cysteine mutation that inhibits binding to thioredoxin [12].
 

Regulatory relationships of Txnip

  • Biochemical analysis showed that mVDUP1 inhibited the insulin-reducing activity of TRX [10].
  • Vitamin D(3) up-regulating protein 1 (VDUP1) antisense DNA regulates tumorigenicity and melanogenesis of murine melanoma cells via regulating the expression of fas ligand and reactive oxygen species [3].
 

Other interactions of Txnip

References

  1. Hepatocellular carcinoma in Txnip-deficient mice. Sheth, S.S., Bodnar, J.S., Ghazalpour, A., Thipphavong, C.K., Tsutsumi, S., Tward, A.D., Demant, P., Kodama, T., Aburatani, H., Lusis, A.J. Oncogene (2006) [Pubmed]
  2. VDUP1 is required for the development of natural killer cells. Lee, K.N., Kang, H.S., Jeon, J.H., Kim, E.M., Yoon, S.R., Song, H., Lyu, C.Y., Piao, Z.H., Kim, S.U., Han, Y.H., Song, S.S., Lee, Y.H., Song, K.S., Kim, Y.M., Yu, D.Y., Choi, I. Immunity (2005) [Pubmed]
  3. Vitamin D(3) up-regulating protein 1 (VDUP1) antisense DNA regulates tumorigenicity and melanogenesis of murine melanoma cells via regulating the expression of fas ligand and reactive oxygen species. Song, H., Cho, D., Jeon, J.H., Han, S.H., Hur, D.Y., Kim, Y.S., Choi, I. Immunol. Lett. (2003) [Pubmed]
  4. Identification of novel molecular candidates for fatty liver in the hyperlipidemic mouse model, HcB19. Van Greevenbroek, M.M., Vermeulen, V.M., De Bruin, T.W. J. Lipid Res. (2004) [Pubmed]
  5. Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Chen, J., Couto, F.M., Minn, A.H., Shalev, A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Positional cloning of the combined hyperlipidemia gene Hyplip1. Bodnar, J.S., Chatterjee, A., Castellani, L.W., Ross, D.A., Ohmen, J., Cavalcoli, J., Wu, C., Dains, K.M., Catanese, J., Chu, M., Sheth, S.S., Charugundla, K., Demant, P., West, D.B., de Jong, P., Lusis, A.J. Nat. Genet. (2002) [Pubmed]
  7. Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1. Jeon, J.H., Lee, K.N., Hwang, C.Y., Kwon, K.S., You, K.H., Choi, I. Cancer Res. (2005) [Pubmed]
  8. Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals. Hui, T.Y., Sheth, S.S., Diffley, J.M., Potter, D.W., Lusis, A.J., Attie, A.D., Davis, R.A. J. Biol. Chem. (2004) [Pubmed]
  9. Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip-/- mice. Donnelly, K.L., Margosian, M.R., Sheth, S.S., Lusis, A.J., Parks, E.J. J. Nutr. (2004) [Pubmed]
  10. Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. Junn, E., Han, S.H., Im, J.Y., Yang, Y., Cho, E.W., Um, H.D., Kim, D.K., Lee, K.W., Han, P.L., Rhee, S.G., Choi, I. J. Immunol. (2000) [Pubmed]
  11. An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells. Cheng, D.W., Jiang, Y., Shalev, A., Kowluru, R., Crook, E.D., Singh, L.P. Arch. Physiol. Biochem. (2006) [Pubmed]
  12. Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production. Chutkow, W.A., Patwari, P., Yoshioka, J., Lee, R.T. J. Biol. Chem. (2008) [Pubmed]
 
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