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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.

AIMS: We assessed the disposition of oral amodiaquine (AQ) and CYP2C8 polymorphism in 20 children with falciparum malaria. METHODS: AQ and DEAQ concentrations were determined with SPE-HPLC method. CYP2C8 genotypes were assessed by PCR-RFLP method. RESULTS: AQ was not detectable beyond day 3 postdose. Cmax for DEAQ was reached in 3.0 days. The mean values for t1/2, MRT, and AUCtotal were 10.1 days, 15.5 days and 4512.6 microg l(-1) day, respectively. All the children were CYP2C8* homozygous. CONCLUSION: Our data are consistent with those previously reported, and the AQ regimen seems pharmacokinetically adequate in the absence of CYP2C8 polymorphism.[1]

References

  1. The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria. Hombhanje, F.W., Hwaihwanje, I., Tsukahara, T., Saruwatari, J., Nakagawa, M., Osawa, H., Paniu, M.M., Takahashi, N., Lum, J.K., Aumora, B., Masta, A., Sapuri, M., Kobayakawa, T., Kaneko, A., Ishizaki, T. British journal of clinical pharmacology. (2005) [Pubmed]
 
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