- Conserved noncoding sequences are selectively constrained and not mutation cold spots. Drake, J.A., Bird, C., Nemesh, J., Thomas, D.J., Newton-Cheh, C., Reymond, A., Excoffier, L., Attar, H., Antonarakis, S.E., Dermitzakis, E.T., Hirschhorn, J.N. Nat. Genet. (2006)