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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

B CELL IMMUNOBIOLOGY IN DISEASE: Evolving Concepts from the Clinic.

The pathogenic roles of B cells in autoimmune diseases occur through several mechanistic pathways that include autoantibodies, immune complexes, dendritic and T cell activation, cytokine synthesis, chemokine-mediated functions, and ectopic neolymphogenesis. Each of these pathways participate to different degrees in autoimmune diseases. The use of B cell-targeted and B cell subset-targeted therapies in humans is illuminating the mechanisms at work in a variety of human autoimmune diseases. In this review, we highlight some of these recent findings that provide insights into both murine models of autoimmunity and human autoimmune diseases.[1]

References

  1. B CELL IMMUNOBIOLOGY IN DISEASE: Evolving Concepts from the Clinic. Martin, F., Chan, A.C. Annu. Rev. Immunol. (2006) [Pubmed]
 
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