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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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EGF receptor activation: push comes to shove.

A study by Zhang et al. (2006) in this issue of Cell provides compelling evidence that the tyrosine kinase domain of the epidermal growth factor receptor ( EGFR) is activated by the formation of an asymmetric dimer, with one kinase domain in the EGF-mediated dimer activating the other through an allosteric mechanism.[1]

References

  1. EGF receptor activation: push comes to shove. Hubbard, S.R. Cell (2006) [Pubmed]
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