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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Design of liposomes for enhanced local release of drugs by hyperthermia.

Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44 degrees C to that at 37 degrees C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection.[1]

References

  1. Design of liposomes for enhanced local release of drugs by hyperthermia. Yatvin, M.B., Weinstein, J.N., Dennis, W.H., Blumenthal, R. Science (1978) [Pubmed]
 
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