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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Dose- and time-response relationships of triethylenemelamine-induced chromosomal aberrations in rat bone marrow cells.

Groups of 18 male Sprague-Dawley rats were administered single i.p. doses of 0.00, 0.125, 0.25 or 0.50 mg/kg of triethylenemelamine (TEM). 6 rats per treatment group were killed 6, 24 or 48 h after dosing, and bone marrow cells were collected and prepared for cytogenetic analysis. Under the present conditions, 0.25 mg/kg with sampling of bone marrow cells 24 h after treatment appeared to represent optimal conditions for using TEM as a positive control agent in the rat in vivo cytogenetic assay as described.[1]

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