Thyroid hormone modulation of X ray-induced in vitro neoplastic transformation.
The direct oncogenic potential of X rays has been demonstrated by the in vitro neoplastic transformation of mammalian cells in culture, a technique which permits the study of oncogenesis in the absence of host-specific effects. Although several agents are known to modulate in vitro neoplastic transformation by X rays, little is known of the effects of hormones. We now describe experiments which show that the presence of thyroid hormone is necessary for in vitro neoplastic transformation by X rays in cells of an established mouse fibroblast culture (C3H/10T1/2) and in early-passage diploid hamster embryo cells.[1]References
- Thyroid hormone modulation of X ray-induced in vitro neoplastic transformation. Guernsey, D.L., Ong, A., Borek, C. Nature (1980) [Pubmed]
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