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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Localization of the transcription factor SP1 gene to human chromosome 12q12-->q13.2.

The cellular transcription factor SP1 binds to critical regulatory elements in a variety of cellular and viral promoters. The gene encoding the approximately 100-kDa SP1 protein contains zinc finger DNA-binding domains and glutamine-activation domains. Since SP1 is involved in the regulation of a variety of cellular genes, we wished to determine its chromosomal localization. Southern blot analysis of genomic DNA from a panel of mouse x human somatic cell hybrids indicated that SP1 was localized to chromosome 12. In situ hybridization allowed the localization of the gene encoding SP1 to human chromosome 12q12-->q13.2, with 12q13.1 being the most probable location.[1]

References

  1. Localization of the transcription factor SP1 gene to human chromosome 12q12-->q13.2. Gaynor, R.B., Shieh, B.H., Klisak, I., Sparkes, R.S., Lusis, A.J. Cytogenet. Cell Genet. (1993) [Pubmed]
 
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