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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 1043 documents. Results 1 - 10.

Mus musculus
Gene: ... dysfunction and hyperphosphorylation of tau, all of which may play critical roles in the pathogenesis...Disease relevance of App In this study, we carried out gene silencing analysis by means of RNA interference with synthetic small interfering RNA duplexes targeting the App, Aplp1 and Aplp2 genes in Neuro2a... / Synonyms: APP; betaAPP; betaApp
Rattus norvegicus
Gene: ... Disease relevance of App There is increasing evidence linking neurodegenerative mechanisms... precursor protein( APP ), and amyloid- beta( Abeta) peptide. Pertussis toxin, which inactivates the heterotrimeric G- proteins Go and Gi, inhibits the apoptosis and DNA synthesis caused by FAD APP mutants... / Synonyms: APP
Saccharomyces cerevisiae S288c
Gene: ... High impact information on APP1 Furthermore, these cofilin mutants provided an opportunity... and function. Cortical recruitment of Sjl2 requires the actin patch component Abp1. Biological context of APP1... compared to wild- type. Other interactions of APP1 SLA1 was identified previously in budding yeast... / Synonyms: Phosphatidate phosphatase APP1
Sus scrofa
Gene: ... Disease relevance of APP Neither hippocampal nor cortical levels of the APP holoprotein( APP( h...( AS ), A. pleuropneumoniae( APP ), and Haemophilus parasuis( HP). Neuronal perikaryal APP expression... information on APP Soluble and membrane- bound isoforms of beta- amyloid protein precursor( APP) of Alzheimer...
Homo sapiens
Gene: ... . We have previously shown that all members of the APP protein family are up- regulated upon retinoic... constant at all ages, while A beta levels dramatically and predictably increased in brain regions.... All the PS1 and PS2 mutations assessed in this series led to enhanced deposition of total Abeta...
Homo sapiens
Gene: ... to be involved also in AD. Other interactions of BACE1 These and other results suggest that memapsin 2 fits all... we show that BACE1 null mice engineered to overexpress human APP( BACE1 (-/-). Tg2576... precursor protein and reduce the cleavage of this protein. Solubilized Asp2 protein cleaves a synthetic APP... / Synonyms: Beta-site APP cleaving enzyme 1
Xenopus laevis
Gene: ... High impact information on app Cells of recombinant clones showed a saturable peptide transport activity for the hydrolysis resistant dipeptide 3H- D- Phe- Ala with an app....
Canis lupus familiaris
Gene: ... High impact information on APP However, deleting the last 42 amino acids( residues 654- 695) or changing tyrosine 653 to alanine altered the distribution of cell surface beta APP so that approximately 40... independent mechanisms mediate the polarized trafficking of beta APP holoprotein and its major secreted...
Bos taurus
Gene: ... of oligodendroglial cytoplasm. All three APP only became elevated around or after the appearance of schizonts...Disease relevance of APP Chromaffin cells were found to synthesize forms of beta APP similar... into their culture medium. Concentrations of APP not only reflect the magnitude of LPS exposure but are also...
Gallus gallus
Gene: ... Disease relevance of APP Although L- type voltage- dependent calcium channels( VDCC) have been implicated in A beta toxicity, the effect of L- type VDCC on APP secretion has not previously been examined. Psychiatry related information on APP These findings suggest that RER and its derivatives may offer a novel...

 

 
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