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Ker Yu

Discovery Oncology and Discovery Medicinal Chemistry

Wyeth Research

Pearl River

New York 10965



Name/email consistency: high



  • Discovery Oncology and Discovery Medicinal Chemistry, Wyeth Research, Pearl River, New York 10965, USA. 2005 - 2010


  1. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Yu, K., Shi, C., Toral-Barza, L., Lucas, J., Shor, B., Kim, J.E., Zhang, W.G., Mahoney, R., Gaydos, C., Tardio, L., Kim, S.K., Conant, R., Curran, K., Kaplan, J., Verheijen, J., Ayral-Kaloustian, S., Mansour, T.S., Abraham, R.T., Zask, A., Gibbons, J.J. Cancer Res. (2010) [Pubmed]
  2. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Yu, K., Toral-Barza, L., Shi, C., Zhang, W.G., Lucas, J., Shor, B., Kim, J., Verheijen, J., Curran, K., Malwitz, D.J., Cole, D.C., Ellingboe, J., Ayral-Kaloustian, S., Mansour, T.S., Gibbons, J.J., Abraham, R.T., Nowak, P., Zask, A. Cancer Res. (2009) [Pubmed]
  3. Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy. Yu, K., Toral-Barza, L., Shi, C., Zhang, W.G., Zask, A. Cancer Biol. Ther. (2008) [Pubmed]
  4. PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors. Yu, K., Lucas, J., Zhu, T., Zask, A., Gaydos, C., Toral-Barza, L., Gu, J., Li, F., Chaudhary, I., Cai, P., Lotvin, J., Petersen, R., Ruppen, M., Fawzi, M., Ayral-Kaloustian, S., Skotnicki, J., Mansour, T., Frost, P., Gibbons, J. Cancer Biol. Ther. (2005) [Pubmed]
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