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Francis Ka Leung Chan

Institute of Digestive Disease

Chinese University of Hong Kong



Name/email consistency: high



  • Institute of Digestive Disease, Chinese University of Hong Kong, China. 2012
  • The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong. 2006 - 2010
  • Department of Medicine & Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin. 1998 - 2007


  1. Editorial: single-tablet ibuprofen/double-dose famotidine for reduction of gastric and duodenal ulcers (REDUCE Trials): what can be reduced? Chan, F.K. Am. J. Gastroenterol. (2012) [Pubmed]
  2. A novel composite endpoint to evaluate the gastrointestinal (GI) effects of nonsteroidal antiinflammatory drugs through the entire GI tract. Chan, F.K., Cryer, B., Goldstein, J.L., Lanas, A., Peura, D.A., Scheiman, J.M., Simon, L.S., Singh, G., Stillman, M.J., Wilcox, C.M., Berger, M.F., Breazna, A., Dodge, W. J. Rheumatol. (2010) [Pubmed]
  3. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Chan, F.K., Lanas, A., Scheiman, J., Berger, M.F., Nguyen, H., Goldstein, J.L. Lancet (2010) [Pubmed]
  4. What is the optimal anti-inflammatory therapy for patients with osteoarthritis and increased cardiovascular risk?. Lai, L.H., Chan, F.L. Nature Clinical Practice. Gastroenterology & Hepatology (2008) [Pubmed]
  5. Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. Chan, F.K., Wong, V.W., Suen, B.Y., Wu, J.C., Ching, J.Y., Hung, L.C., Hui, A.J., Leung, V.K., Lee, V.W., Lai, L.H., Wong, G.L., Chow, D.K., To, K.F., Leung, W.K., Chiu, P.W., Lee, Y.T., Lau, J.Y., Chan, H.L., Ng, E.K., Sung, J.J. Lancet (2007) [Pubmed]
  6. Proton-pump inhibitors as a protective treatment for high-risk patients receiving treatment with NSAIDs. Chan, F.K. Nature Clinical Practice. Rheumatology (2007) [Pubmed]
  7. Management of high-risk patients on non-steroidal anti-inflammatory drugs or aspirin. Chan, F.K. Drugs (2006) [Pubmed]
  8. Primer: managing NSAID-induced ulcer complications--balancing gastrointestinal and cardiovascular risks. Chan, F.K. Nature Clinical Practice. Gastroenterology & Hepatology (2006) [Pubmed]
  9. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. Chan, F.K., Ching, J.Y., Hung, L.C., Wong, V.W., Leung, V.K., Kung, N.N., Hui, A.J., Wu, J.C., Leung, W.K., Lee, V.W., Lee, K.K., Lee, Y.T., Lau, J.Y., To, K.F., Chan, H.L., Chung, S.C., Sung, J.J. N. Engl. J. Med. (2005) [Pubmed]
  10. Should we eradicate Helicobacter pylori infection in patients receiving nonsteroidal anti-inflammatory drugs or low-dose aspirin?. Chan, F.K. Chin. J. Dig. Dis (2005) [Pubmed]
  11. NSAID-induced peptic ulcers and Helicobacter pylori infection: implications for patient management. Chan, F.K. Drug. Saf (2005) [Pubmed]
  12. Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial. Chan, F.K., Hung, L.C., Suen, B.Y., Wong, V.W., Hui, A.J., Wu, J.C., Leung, W.K., Lee, Y.T., To, K.F., Chung, S.C., Sung, J.J. Gastroenterology (2004) [Pubmed]
  13. COX-2 inhibition, H. pylori infection and the risk of gastrointestinal complications. Chan, F.K. Curr. Pharm. Des. (2003) [Pubmed]
  14. Helicobacter pylori, NSAIDs and gastrointestinal haemorrhage. Chan, F.K. Eur. J. Gastroenterol. Hepatol (2002) [Pubmed]
  15. Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial. Chan, F.K., To, K.F., Wu, J.C., Yung, M.Y., Leung, W.K., Kwok, T., Hui, Y., Chan, H.L., Chan, C.S., Hui, E., Woo, J., Sung, J.J. Lancet (2002) [Pubmed]
  16. Peptic-ulcer disease. Chan, F.K., Leung, W.K. Lancet (2002) [Pubmed]
  17. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. Chan, F.K., Hung, L.C., Suen, B.Y., Wu, J.C., Lee, K.C., Leung, V.K., Hui, A.J., To, K.F., Leung, W.K., Wong, V.W., Chung, S.C., Sung, J.J. N. Engl. J. Med. (2002) [Pubmed]
  18. Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs. Chan, F.K., Sung, J.J., Ching, J.Y., Wu, J.C., Lee, Y.T., Leung, W.K., Hui, Y., Chan, L.Y., Lai, A.C., Chung, S.C. Aliment. Pharmacol. Ther. (2001) [Pubmed]
  19. Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis. Chan, F.K., To, K.F., Ng, Y.P., Lee, T.L., Cheng, A.S., Leung, W.K., Sung, J.J. Aliment. Pharmacol. Ther. (2001) [Pubmed]
  20. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. Chan, F.K., Chung, S.C., Suen, B.Y., Lee, Y.T., Leung, W.K., Leung, V.K., Wu, J.C., Lau, J.Y., Hui, Y., Lai, M.S., Chan, H.L., Sung, J.J. N. Engl. J. Med. (2001) [Pubmed]
  21. Helicobacter pylori and nonsteroidal anti-inflammatory drugs. Chan, F.K. Gastroenterol. Clin. North Am. (2001) [Pubmed]
  22. Salvage therapies after failure of Helicobacter pylori eradication with ranitidine bismuth citrate-based therapies. Chan, F.K., Sung, J.J., Suen, R., Wu, J.C., Ling, T.K., Chung, S.C. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  23. Protein-losing enteropathy in congestive heart failure: diagnosis by means of a simple method. Chan, F.K., Sung, J.J., Ma, K.M., Leung, Y.L., Yeung, V.T. Hepatogastroenterology (1999) [Pubmed]
  24. Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study. Chan, F.K., Sung, J.J., Suen, R., Lee, Y.T., Wu, J.C., Leung, W.K., Chan, H.L., Lai, A.C., Lau, J.Y., Ng, E.K., Chung, S.C. Aliment. Pharmacol. Ther. (1998) [Pubmed]
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