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Chan, F.K. et al.

Chan, To, Ng, Lee, Cheng, Leung, Sung,

Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis.

BACKGROUND: There are conflicting reports on the expression of cyclooxygenase in Helicobacter pylori infection. AIM: To evaluate the expression of COX-1 and COX-2 in H. pylori gastritis at messenger RNA (mRNA) and protein levels. METHODS: Endoscopic gastric biopsies were obtained from patients with non-ulcer dyspepsia. The levels of COX-1 and COX-2 mRNA were compared between H. pylori-infected and uninfected specimens using reverse transcription-polymerase chain reaction. The immunohistochemical findings were correlated with the cellular localization of cyclooxygenase mRNA using in situ hybridization. RESULTS: A total of 40 H. pylori-infected and 40 uninfected specimens were studied. mRNA of COX-2 but not COX-1 was elevated in H. pylori-infected mucosa. COX-1 was localized to the mononuclear inflammatory, endothelial and smooth muscle cells in the lamina propria. COX-2 was barely detectable in uninfected mucosa but was strongly expressed in the foveolar and glandular epithelia in H. pylori gastritis. CONCLUSION: Cyclooxygenase-1 is expressed in the mononuclear inflammatory, endothelial and smooth muscle cells in the lamina propria irrespective of the H. pylori status. By contrast, H. pylori induces COX-2 expression in the foveolar and glandular epithelia.[1]

References

Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis. Chan, F.K., To, K.F., Ng, Y.P., Lee, T.L., Cheng, A.S., Leung, W.K., Sung, J.J. Aliment. Pharmacol. Ther. (2001) [Pubmed]

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