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Akinori Iwashita

Exploratory Research Laboratories

Fujisawa Pharmaceutical Co.

Ltd., 2-1-6 Kashima




Name/email consistency: high



  • Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Japan. 2003 - 2005


  1. Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors. Iwashita, A., Hattori, K., Yamamoto, H., Ishida, J., Kido, Y., Kamijo, K., Murano, K., Miyake, H., Kinoshita, T., Warizaya, M., Ohkubo, M., Matsuoka, N., Mutoh, S. FEBS Lett. (2005) [Pubmed]
  2. Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Iwashita, A., Yamazaki, S., Mihara, K., Hattori, K., Yamamoto, H., Ishida, J., Matsuoka, N., Mutoh, S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  3. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. Iwashita, A., Tojo, N., Matsuura, S., Yamazaki, S., Kamijo, K., Ishida, J., Yamamoto, H., Hattori, K., Matsuoka, N., Mutoh, S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  4. A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice. Iwashita, A., Mihara, K., Yamazaki, S., Matsuura, S., Ishida, J., Yamamoto, H., Hattori, K., Matsuoka, N., Mutoh, S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  5. A novel potent radical scavenger, 8-(4-fluorophenyl)-2-((2E)-3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo[5,1-c] [1,2,4]triazine (FR210575), prevents neuronal cell death in cultured primary neurons and attenuates brain injury after focal ischemia in rats. Iwashita, A., Maemoto, T., Nakada, H., Shima, I., Matsuoka, N., Hisajima, H. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
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