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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

James C. Barton

Southern Iron Disorders Center


Alabama 35209



Name/email consistency: low



  • Southern Iron Disorders Center, Birmingham, Alabama 35209, USA. 1999 - 2009
  • Southern Iron Disorders Center and Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35209, USA. 2001 - 2009
  • Southern Iron Disorders Center, G-105, 2022 Brookwood Medical Center Drive, Birmingham, USA. 2000 - 2008
  • Department of Medicine, Brookwood Medical Center, Birmingham, Alabama, USA. 2003 - 2004


  1. Hypogonadotrophic hypogonadism due to intrasellar hemangioblastoma in von Hippel-Lindau syndrome. Barton, J.C., Goncalves, E., Santani, A., Chandra-Sekar, B., Morris, E.C., Carter, B.B., Stolle, C.A. Am. J. Med. Genet. A (2009) [Pubmed]
  2. A comparison between whites and blacks with severe multi-organ iron overload identified in 16,152 autopsies. Barton, J.C., Acton, R.T., Anderson, L.E., Alexander, C.B. Clin. Gastroenterol. Hepatol. (2009) [Pubmed]
  3. Hemochromatosis and Vibrio vulnificus wound infections. Barton, J.C., Acton, R.T. J. Clin. Gastroenterol. (2009) [Pubmed]
  4. HFE hemochromatosis and hepatic sarcoid. Barton, J.C., McGuire, B.M., Acton, R.T. Am. J. Med. Sci. (2009) [Pubmed]
  5. HFE, SLC40A1, HAMP, HJV, TFR2, and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants. Barton, J.C., Lafreniere, S.A., Leiendecker-Foster, C., Li, H., Acton, R.T., Press, R.D., Eckfeldt, J.H. Am. J. Hematol. (2009) [Pubmed]
  6. Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening. Barton, J.C., Acton, R.T., Leiendecker-Foster, C., Lovato, L., Adams, P.C., Eckfeldt, J.H., McLaren, C.E., Reiss, J.A., McLaren, G.D., Reboussin, D.M., Gordeuk, V.R., Speechley, M.R., Press, R.D., Dawkins, F.W. Am. J. Hematol. (2008) [Pubmed]
  7. Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS study. Barton, J.C., Leiendecker-Foster, C., Reboussin, D.M., Adams, P.C., Acton, R.T., Eckfeldt, J.H. Thyroid (2008) [Pubmed]
  8. Chelation therapy for iron overload. Barton, J.C. Curr. Gastroenterol. Rep (2007) [Pubmed]
  9. Optimal management strategies for chronic iron overload. Barton, J.C. Drugs (2007) [Pubmed]
  10. Drug evaluation: deferitrin (GT-56-252; NaHBED) for iron overload disorders. Barton, J.C. IDrugs (2007) [Pubmed]
  11. SLC40A1 Q248H allele frequencies and Q248H-associated risk of non-HFE iron overload in persons of sub-Saharan African descent. Barton, J.C., Acton, R.T., Lee, P.L., West, C. Blood Cells Mol. Dis. (2007) [Pubmed]
  12. Drug evaluation: Deferitrin for iron overload disorders. Barton, J.C. IDrugs (2007) [Pubmed]
  13. HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screening. Barton, J.C., Acton, R.T., Leiendecker-Foster, C., Lovato, L., Adams, P.C., McLaren, G.D., Eckfeldt, J.H., McLaren, C.E., Reboussin, D.M., Gordeuk, V.R., Speechley, M.R., Reiss, J.A., Press, R.D., Dawkins, F.W. Genet. Test. (2007) [Pubmed]
  14. Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study. Barton, J.C., Acton, R.T., Lovato, L., Speechley, M.R., McLaren, C.E., Harris, E.L., Reboussin, D.M., Adams, P.C., Dawkins, F.W., Gordeuk, V.R., Walker, A.P. Clin. Genet. (2006) [Pubmed]
  15. Effect of Native American ancestry on iron-related phenotypes of Alabama hemochromatosis probands with HFE C282Y homozygosity. Barton, J.C., Barton, E.H., Acton, R.T. BMC Med. Genet. (2006) [Pubmed]
  16. Disparate phenotypic expression of ALAS2 R452H (nt 1407 G --> A) in two brothers, one with severe sideroblastic anemia and iron overload, hepatic cirrhosis, and hepatocellular carcinoma. Barton, J.C., Lee, P.L. Blood Cells Mol. Dis. (2006) [Pubmed]
  17. Iron overload and prolonged ingestion of iron supplements: clinical features and mutation analysis of hemochromatosis-associated genes in four cases. Barton, J.C., Lee, P.L., West, C., Bottomley, S.S. Am. J. Hematol. (2006) [Pubmed]
  18. Vibrio vulnificus bacteremia associated with chronic lymphocytic leukemia, hypogammaglobulinemia, and hepatic cirrhosis: relation to host and exposure factors in 252 V. vulnificus infections reported in Louisiana. Barton, J.C., Ratard, R.C. Am. J. Med. Sci. (2006) [Pubmed]
  19. HLA haplotype A*03-B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack of association with severity of iron overload. Barton, J.C., Wiener, H.W., Acton, R.T., Go, R.C. Blood Cells Mol. Dis. (2005) [Pubmed]
  20. Deferasirox Novartis. Barton, J.C. Curr. Opin. Investig. Drugs (2005) [Pubmed]
  21. Iron overload in an African American woman with SS hemoglobinopathy and a promoter mutation in the X-linked erythroid-specific 5-aminolevulinate synthase (ALAS2) gene. Barton, J.C., Lee, P.L., Bertoli, L.F., Beutler, E. Blood Cells Mol. Dis. (2005) [Pubmed]
  22. Total blood lymphocyte counts in hemochromatosis probands with HFE C282Y homozygosity: relationship to severity of iron overload and HLA-A and -B alleles and haplotypes. Barton, J.C., Wiener, H.W., Acton, R.T., Go, R.C. BMC. Blood. Disord (2005) [Pubmed]
  23. Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study. Barton, J.C., Acton, R.T., Dawkins, F.W., Adams, P.C., Lovato, L., Leiendecker-Foster, C., McLaren, C.E., Reboussin, D.M., Speechley, M.R., Gordeuk, V.R., McLaren, G.D., Sholinsky, P., Harris, E.L. Genet. Test. (2005) [Pubmed]
  24. HFE C282Y and H63D in adults with malignancies in a community medical oncology practice. Barton, J.C., Bertoli, L.F., Acton, R.T. BMC. Cancer (2004) [Pubmed]
  25. A previously undescribed frameshift deletion mutation of HFE (c.del277; G93fs) associated with hemochromatosis and iron overload in a C282Y heterozygote. Barton, J.C., West, C., Lee, P.L., Beutler, E. Clin. Genet. (2004) [Pubmed]
  26. Characteristics of HFE C282Y homozygotes younger than age 30 years. Barton, J.C., Felitti, V.J., Lee, P., Beutler, E. Acta Haematol. (2004) [Pubmed]
  27. Hemochromatosis, HFE C282Y homozygosity, and bariatric surgery: report of three cases. Barton, J.C. Obes. Surg (2004) [Pubmed]
  28. Allele frequencies of hemojuvelin gene (HJV) I222N and G320V missense mutations in white and African American subjects from the general Alabama population. Barton, J.C., Rivers, C.A., Niyongere, S., Bohannon, S.B., Acton, R.T. BMC Med. Genet. (2004) [Pubmed]
  29. HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama. Barton, J.C., Bertoli, L.F., Acton, R.T. BMC Med. Genet. (2003) [Pubmed]
  30. Common variable immunodeficiency and IgG subclass deficiency in central Alabama hemochromatosis probands homozygous for HFE C282Y. Barton, J.C., Bertoli, L.F., Acton, R.T. Blood Cells Mol. Dis. (2003) [Pubmed]
  31. Vibrio vulnificus infection in a hemodialysis patient receiving intravenous iron therapy. Barton, J.C., Coghlan, M.E., Reymann, M.T., Ozbirn, T.W., Acton, R.T. Clin. Infect. Dis. (2003) [Pubmed]
  32. Thalidomide and dexamethasone therapy of myeloma in a patient with previously untreated B-chronic lymphocytic leukemia. Barton, J.C. Am. J. Hematol. (2003) [Pubmed]
  33. Genotypic and phenotypic heterogeneity of African Americans with primary iron overload. Barton, J.C., Acton, R.T., Rivers, C.A., Bertoli, L.F., Gelbart, T., West, C., Beutler, E. Blood Cells Mol. Dis. (2003) [Pubmed]
  34. HLA-A and -B alleles and haplotypes in hemochromatosis probands with HFE C282Y homozygosity in central Alabama. Barton, J.C., Acton, R.T. BMC Med. Genet. (2002) [Pubmed]
  35. Juvenile hemochromatosis in the southeastern United States: a report of seven cases in two kinships. Barton, J.C., Rao, S.V., Pereira, N.M., Gelbart, T., Beutler, E., Rivers, C.A., Acton, R.T. Blood Cells Mol. Dis. (2002) [Pubmed]
  36. Severity of iron overload in hemochromatosis: effect of volunteer blood donation before diagnosis. Barton, J.C., Preston, B.L., McDonnell, S.M., Rothenberg, B.E. Transfusion (2001) [Pubmed]
  37. Screening for hemochromatosis in routine medical care: an evaluation of mean corpuscular volume and mean corpuscular hemoglobin. Barton, J.C., Bertoli, L.F., Rothenberg, B.E. Genet. Test. (2000) [Pubmed]
  38. Transferrin saturation phenotype and HFE genotype screening for hemochromatosis and primary iron overload: predictions from a model based on national, racial, and ethnic group composition in central Alabama. Barton, J.C., Acton, R.T. Genet. Test. (2000) [Pubmed]
  39. Population screening for hemochromatosis: has the time finally come?. Barton, J.C., Acton, R.T. Curr. Gastroenterol. Rep (2000) [Pubmed]
  40. Iron deficiency due to excessive therapeutic phlebotomy in hemochromatosis. Barton, J.C., Bottomley, S.S. Am. J. Hematol. (2000) [Pubmed]
  41. Hemochromatosis probands as blood donors. Barton, J.C., Grindon, A.J., Barton, N.H., Bertoli, L.F. Transfusion (1999) [Pubmed]
  42. Two novel missense mutations of the HFE gene (I105T and G93R) and identification of the S65C mutation in Alabama hemochromatosis probands. Barton, J.C., Sawada-Hirai, R., Rothenberg, B.E., Acton, R.T. Blood Cells Mol. Dis. (1999) [Pubmed]
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