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Jose de Leon

University of Kentucky Mental Health Research Center at Eastern State Hospital

627 West Fourth St.

Lexington

KY, 40508

USA

[email]@uky.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth St., Lexington, KY, 40508, USA. 2009 - 2012
  • Mental Health Research Center, Eastern State Hospital, Lexington, KY USA. E-mail:. 2002 - 2011

References

  1. Genetics of schizophrenia and smoking: an approach to studying their comorbidity based on epidemiological findings. de Leon, J., Diaz, F.J. Hum. Genet. (2012) [Pubmed]
  2. Interactions between antiepileptics and second-generation antipsychotics. de Leon, J., Santoro, V., D'Arrigo, C., Spina, E. Expert. Opin. Drug. Metab. Toxicol (2012) [Pubmed]
  3. Lack of replication of the association of low serum cholesterol and attempted suicide in another country raises more questions. de Leon, J., Mallory, P., Maw, L., Susce, M.T., Perez-Rodriguez, M.M., Baca-Garcia, E. Ann. Clin. Psychiatry (2011) [Pubmed]
  4. The pharmacokinetics of paliperidone versus risperidone. de Leon, J., Wynn, G., Sandson, N.B. Psychosomatics (2010) [Pubmed]
  5. Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities. de Leon, J., Greenlee, B., Barber, J., Sabaawi, M., Singh, N.N. Res. Dev. Disabil (2009) [Pubmed]
  6. Pharmacogenomics: the promise of personalized medicine for CNS disorders. de Leon, J. Neuropsychopharmacology (2009) [Pubmed]
  7. DNA microarray technology in the clinical environment: the AmpliChip CYP450 test for CYP2D6 and CYP2C19 genotyping. de Leon, J., Susce, M.T., Johnson, M., Hardin, M., Maw, L., Shao, A., Allen, A.C., Chiafari, F.A., Hillman, G., Nikoloff, D.M. CNS. Spectr (2009) [Pubmed]
  8. The future (or lack of future) of personalized prescription in psychiatry. de Leon, J. Pharmacol. Res. (2009) [Pubmed]
  9. A preliminary attempt to personalize risperidone dosing using drug-drug interactions and genetics: part II. de Leon, J., Sandson, N.B., Cozza, K.L. Psychosomatics (2008) [Pubmed]
  10. Pharmacogenetic testing in psychiatry: a review of features and clinical realities. de Leon, J., Arranz, M.J., Ruaño, G. Clin. Lab. Med. (2008) [Pubmed]
  11. A preliminary attempt to personalize risperidone dosing using drug-drug interactions and genetics: part I. de Leon, J., Sandson, N.B., Cozza, K.L. Psychosomatics (2008) [Pubmed]
  12. Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels. de Leon, J., Correa, J.C., Ruaño, G., Windemuth, A., Arranz, M.J., Diaz, F.J. Schizophr. Res. (2008) [Pubmed]
  13. Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports. de Leon, J., Nikoloff, D.M. CNS. Spectr (2008) [Pubmed]
  14. A clinical study of the association of antipsychotics with hyperlipidemia. de Leon, J., Susce, M.T., Johnson, M., Hardin, M., Pointer, L., Ruaño, G., Windemuth, A., Diaz, F.J. Schizophr. Res. (2007) [Pubmed]
  15. Association between smoking and alcohol use in the general population: stable and unstable odds ratios across two years in two different countries. De Leon, J., Rendon, D.M., Baca-Garcia, E., Aizpuru, F., Gonzalez-Pinto, A., Anitua, C., Diaz, F.J. Alcohol Alcohol. (2007) [Pubmed]
  16. Weight gain during a double-blind multidosage clozapine study. de Leon, J., Diaz, F.J., Josiassen, R.C., Cooper, T.B., Simpson, G.M. J. Clin. Psychopharmacol (2007) [Pubmed]
  17. The effect of atypical versus typical antipsychotics on tardive dyskinesia: a naturalistic study. de Leon, J. Eur. Arch. Psychiatry. Clin. Neurosci (2007) [Pubmed]
  18. A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels. Leon, J., Susce, M.T., Pan, R.M., Wedlund, P.J., Orrego, M.L., Diaz, F.J. Pharmacopsychiatry (2007) [Pubmed]
  19. Planning for the optimal design of studies to personalize antipsychotic prescriptions in the post-CATIE era: the clinical and pharmacoepidemiological data suggest that pursuing the pharmacogenetics of metabolic syndrome complications (hypertension, diabetes mellitus and hyperlipidemia) may be a reasonable strategy. de Leon, J., Diaz, F.J. Schizophr. Res. (2007) [Pubmed]
  20. Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19. de Leon, J., Armstrong, S.C., Cozza, K.L. Psychosomatics (2006) [Pubmed]
  21. AmpliChip CYP450 test: personalized medicine has arrived in psychiatry. de Leon, J. Expert Rev. Mol. Diagn. (2006) [Pubmed]
  22. The AmpliChip CYP450 genotyping test: Integrating a new clinical tool. de Leon, J., Susce, M.T., Murray-Carmichael, E. Molecular. Diagnosis. &. Therapy (2006) [Pubmed]
  23. Does smoking reduce akathisia? Testing a narrow version of the self-medication hypothesis. de Leon, J., Diaz, F.J., Aguilar, M.C., Jurado, D., Gurpegui, M. Schizophr. Res. (2006) [Pubmed]
  24. The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. de Leon, J., Susce, M.T., Pan, R.M., Fairchild, M., Koch, W.H., Wedlund, P.J. J. Clin. Psychiatry (2005) [Pubmed]
  25. A brief measure of high nicotine dependence for busy clinicians and large epidemiological surveys. Diaz, F.J., Jané, M., Saltó, E., Pardell, H., Salleras, L., Pinet, C., de Leon, J. Aust. N. Z. J. Psychiatry (2005) [Pubmed]
  26. The dosing of atypical antipsychotics. de Leon, J., Armstrong, S.C., Cozza, K.L. Psychosomatics (2005) [Pubmed]
  27. A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors. de Leon, J., Diaz, F.J. Schizophr. Res. (2005) [Pubmed]
  28. Does clozapine decrease smoking?. de Leon, J., Diaz, F.J., Josiassen, R.C., Cooper, T.B., Simpson, G.M. Prog. Neuropsychopharmacol. Biol. Psychiatry (2005) [Pubmed]
  29. Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness. de Leon, J., Susce, M.T., Pan, R.M., Koch, W.H., Wedlund, P.J. J. Clin. Psychopharmacol (2005) [Pubmed]
  30. Variables associated with alcohol, drug, and daily smoking cessation in patients with severe mental illnesses. de Leon, J., Susce, M.T., Diaz, F.J., Rendon, D.M., Velásquez, D.M. J. Clin. Psychiatry (2005) [Pubmed]
  31. Psychopharmacology: atypical antipsychotic dosing: the effect of co-medication with anticonvulsants. de Leon, J. Psychiatr. Serv (2004) [Pubmed]
  32. Atypical antipsychotic dosing: the effect of smoking and caffeine. de Leon, J. Psychiatr. Serv (2004) [Pubmed]
  33. Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment. de Leon, J., Diaz, F.J., Josiassen, R.C., Simpson, G.M. Eur. Arch. Psychiatry. Clin. Neurosci (2004) [Pubmed]
  34. Haloperidol half-life after chronic dosing. de Leon, J., Diaz, F.J., Wedlund, P., Josiassen, R.C., Cooper, T.B., Simpson, G.M. J. Clin. Psychopharmacol (2004) [Pubmed]
  35. A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers. de Leon, J., Diaz, F.J., Rogers, T., Browne, D., Dinsmore, L., Ghosheh, O.H., Dwoskin, L.P., Crooks, P.A. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003) [Pubmed]
  36. Polydipsia--a study in a long-term psychiatric unit. de Leon, J. Eur. Arch. Psychiatry. Clin. Neurosci (2003) [Pubmed]
  37. Glucuronidation enzymes, genes and psychiatry. de Leon, J. Int. J. Neuropsychopharmacol. (2003) [Pubmed]
  38. Serum antimuscarinic activity during clozapine treatment. de Leon, J., Odom-White, A., Josiassen, R.C., Diaz, F.J., Cooper, T.B., Simpson, G.M. J. Clin. Psychopharmacol (2003) [Pubmed]
  39. Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report. de Leon, J., Diaz, F.J. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003) [Pubmed]
  40. Exploring brief measures of nicotine dependence for epidemiological surveys. de Leon, J., Diaz, F.J., Becoña, E., Gurpegui, M., Jurado, D., Gonzalez-Pinto, A. Addict. Behav (2003) [Pubmed]
  41. Polydipsia and schizophrenia in a psychiatric hospital: a replication study. de Leon, J., Tracy, J., McCann, E., McGrory, A. Schizophr. Res. (2002) [Pubmed]
  42. Total cotinine in plasma: a stable biomarker for exposure to tobacco smoke. de Leon, J., Diaz, F.J., Rogers, T., Browne, D., Dinsmore, L., Ghosheh, O.H., Dwoskin, L.P., Crooks, P.A. J. Clin. Psychopharmacol (2002) [Pubmed]
 
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