Józefa Wesierska-Gadek
Cell Cycle Regulation Group
Division: Institute of Cancer Research
Dept of Medicine I
Comprehensive Cancer Center
Austria
Name/email consistency: high
- The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules. Węsierska-Gądek, J., Krame, M.P. Future. Med. Chem (2012)
- The impact of multi-targeted cyclin-dependent kinase inhibition in breast cancer cells: clinical implications. Węsierska-Gądek, J., Kramer, M.P. Expert. Opin. Investig. Drugs (2011)
- Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells. Węsierska-Gądek, J., Gritsch, D., Zulehner, N., Komina, O., Maurer, M. J. Cell. Biochem. (2011)
- Promotion of apoptosis in cancer cells by selective purine-derived pharmacological CDK inhibitors: one outcome, many mechanisms. Węsierska-Gądek, J., Maurer, M. Curr. Pharm. Des. (2011)
- Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells. Węsierska-Gądek, J., Gritsch, D., Zulehner, N., Komina, O., Maurer, M. J. Cell. Biochem. (2011)
- Reconstitution of human MCF-7 breast cancer cells with caspase-3 does not sensitize them to action of CDK inhibitors. Węsierska-Gądek, J., Hackl, S., Zulehner, N., Maurer, M., Komina, O. J. Cell. Biochem. (2011)
- Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment. Wesierska-Gadek, J., Borza, A., Walzi, E., Krystof, V., Maurer, M., Komina, O., Wandl, S. J. Cell. Biochem. (2009)
- Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential. Wesierska-Gadek, J., Borza, A., Komina, O., Maurer, M. Acta Biochim. Pol. (2009)
- Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia? Wesierska-Gadek, J., Krystof, V. Ann. N. Y. Acad. Sci. (2009)
- Oncogenes do not Fully Override Cell-intrinsic Traits: Pronounced Impact of the Cellular Programme. Węsierska-Gądek, J., Walzi, E., Dolečkova, I., Schmid, G. Cancer. Microenviron (2009)
- Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells. Wesierska-Gadek, J., Hajek, S.B., Sarg, B., Wandl, S., Walzi, E., Lindner, H. Biochem. Pharmacol. (2008)
- Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells. Wesierska-Gadek, J., Kramer, M.P., Maurer, M. Food Chem. Toxicol. (2008)
- Signaling of DNA damage is not sufficient to induce p53 response: (re)activation of wt p53 protein strongly depends on cellular context. Wesierska-Gadek, J., Gueorguieva, M., Komina, O., Schmid, G., Kramer, M.P. J. Cell. Biochem. (2008)
- Characterization of the antibodies to p62 nucleoporin in primary biliary cirrhosis using human recombinant antigen. Wesierska-Gadek, J., Klima, A., Ranftler, C., Komina, O., Hanover, J., Invernizzi, P., Penner, E. J. Cell. Biochem. (2008)
- Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells. Wesierska-Gadek, J., Wandl, S., Kramer, M.P., Pickem, C., Krystof, V., Hajek, S.B. J. Cell. Biochem. (2008)
- A combined treatment of HeLa cells with the farnesyl protein transferase inhibitor L-744,832 and cisplatin significantly increases the therapeutic effect as compared to cisplatin monotherapy. Wesierska-Gadek, J., Kramer, M.P., Schmid, G. J. Cell. Biochem. (2008)
- Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells. Wesierska-Gadek, J., Schmitz, M.L., Ranftler, C. J. Cell. Biochem. (2007)
- Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine. Wesierska-Gadek, J., Schreiner, T., Maurer, M., Waringer, A., Ranftler, C. Cell. Mol. Biol. Lett. (2007)
- Characterization of autoantibodies against components of the nuclear pore complexes: high frequency of anti-p62 nucleoporin antibodies. Wesierska-Gadek, J., Klima, A., Komina, O., Ranftler, C., Invernizzi, P., Penner, E. Ann. N. Y. Acad. Sci. (2007)
- A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein. Wesierska-Gadek, J., Gueorguieva, M., Kramer, M.P., Ranftler, C., Sarg, B., Lindner, H. J. Cell. Biochem. (2007)
- Inhibition of farnesyl protein transferase sensitizes human MCF-7 breast cancer cells to roscovitine-mediated cell cycle arrest. Wesierska-Gadek, J., Maurer, M., Schmid, G. J. Cell. Biochem. (2007)
- Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells. Wesierska-Gadek, J., Gueorguieva, M., Herbacek, I., Ranftler, C. Ann. N. Y. Acad. Sci. (2007)
- Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein. Wesierska-Gadek, J., Schmid, G. Expert. Opin. Investig. Drugs (2006)
- Phenol red reduces ROSC mediated cell cycle arrest and apoptosis in human MCF-7 cells. Wesierska-Gadek, J., Schreiner, T., Gueorguieva, M., Ranftler, C. J. Cell. Biochem. (2006)
- Prevention of farnesylation of c-Ha-Ras protein enhances synergistically the cytotoxic action of doxorubicin in cycling but not in quiescent cells. Wesierska-Gadek, J., Kramer, M., Schmid, G. J. Cell. Biochem. (2006)
- Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. Wesierska-Gadek, J., Gueorguieva, M., Horky, M. Mol. Cancer Ther. (2005)
- Role of p53 tumor suppressor in ageing: regulation of transient cell cycle arrest and terminal senescence. Wesierska-Gadek, J., Wojciechowski, J., Ranftler, C., Schmid, G. J. Physiol. Pharmacol. (2005)
- Major contribution of the multidrug transporter P-glycoprotein to reduced susceptibility of poly(ADP-ribose) polymerase-1 knock-out cells to doxorubicin action. Wesierska-Gadek, J. J. Cell. Biochem. (2005)
- A new multiplex assay allowing simultaneous detection of the inhibition of cell proliferation and induction of cell death. Wesierska-Gadek, J., Gueorguieva, M., Ranftler, C., Zerza-Schnitzhofer, G. J. Cell. Biochem. (2005)
- Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence. Wesierska-Gadek, J., Ranftler, C., Schmid, G. J. Physiol. Pharmacol. (2005)
- The subcellular distribution of the p53 tumour suppressor, and organismal ageing. Wesierska-Gadek, J., Schmid, G. Cell. Mol. Biol. Lett. (2005)
- Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest. Wesierska-Gadek, J., Schloffer, D., Gueorguieva, M., Uhl, M., Skladanowski, A. Cancer Res. (2004)
- In vivo activated caspase-3 cleaves PARP-1 in rat liver after administration of the hepatocarcinogen N-nitrosomorpholine (NNM) generating the 85 kDa fragment. Wesierska-Gadek, J., Gueorguieva, M., Wojciechowski, J., Tudzarova-Trajkovska, S. J. Cell. Biochem. (2004)
