Klaus Klumpp
Roche Palo Alto LLC
Palo Alto
California 94304
USA
Name/email consistency: high
- 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. Klumpp, K., Kalayanov, G., Ma, H., Le Pogam, S., Leveque, V., Jiang, W.R., Inocencio, N., De Witte, A., Rajyaguru, S., Tai, E., Chanda, S., Irwin, M.R., Sund, C., Winqist, A., Maltseva, T., Eriksson, S., Usova, E., Smith, M., Alker, A., Najera, I., Cammack, N., Martin, J.A., Johansson, N.G., Smith, D.B. J. Biol. Chem. (2008)
- The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. Klumpp, K., Lévêque, V., Le Pogam, S., Ma, H., Jiang, W.R., Kang, H., Granycome, C., Singer, M., Laxton, C., Hang, J.Q., Sarma, K., Smith, D.B., Heindl, D., Hobbs, C.J., Merrett, J.H., Symons, J., Cammack, N., Martin, J.A., Devos, R., Nájera, I. J. Biol. Chem. (2006)
- Optimization of small molecule drugs binding to highly polar target sites: lessons from the discovery and development of neuraminidase inhibitors. Klumpp, K., Graves, B.J. Curr. Top. Med. Chem (2006)
- Recent progress in the design of small molecule inhibitors of HIV RNase H. Klumpp, K., Mirzadegan, T. Curr. Pharm. Des. (2006)
- Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors. Klumpp, K., Hang, J.Q., Rajendran, S., Yang, Y., Derosier, A., Wong Kai In, P., Overton, H., Parkes, K.E., Cammack, N., Martin, J.A. Nucleic Acids Res. (2003)
- RNA and DNA hydrolysis are catalyzed by the influenza virus endonuclease. Klumpp, K., Doan, L., Roberts, N.A., Handa, B. J. Biol. Chem. (2000)
- Variation in ATP requirement during influenza virus transcription. Klumpp, K., Ford, M.J., Ruigrok, R.W. J. Gen. Virol. (1998)
