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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Klaus Klumpp

Roche Palo Alto LLC

Palo Alto

California 94304

USA

[email]@roche.com

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • Roche Palo Alto LLC, Palo Alto, California 94304, USA. 2006 - 2008
  • Roche Discovery Welwyn, Welwyn Garden City, UK. 2003
  • Roche Discovery Welwyn, 40 Broadwater Road, Welwyn Garden City, Herts AL7 3AY, United Kingdom. 2000
  • EMBL Grenoble Outstation, France. 1998

References

  1. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. Klumpp, K., Kalayanov, G., Ma, H., Le Pogam, S., Leveque, V., Jiang, W.R., Inocencio, N., De Witte, A., Rajyaguru, S., Tai, E., Chanda, S., Irwin, M.R., Sund, C., Winqist, A., Maltseva, T., Eriksson, S., Usova, E., Smith, M., Alker, A., Najera, I., Cammack, N., Martin, J.A., Johansson, N.G., Smith, D.B. J. Biol. Chem. (2008) [Pubmed]
  2. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. Klumpp, K., Lévêque, V., Le Pogam, S., Ma, H., Jiang, W.R., Kang, H., Granycome, C., Singer, M., Laxton, C., Hang, J.Q., Sarma, K., Smith, D.B., Heindl, D., Hobbs, C.J., Merrett, J.H., Symons, J., Cammack, N., Martin, J.A., Devos, R., Nájera, I. J. Biol. Chem. (2006) [Pubmed]
  3. Optimization of small molecule drugs binding to highly polar target sites: lessons from the discovery and development of neuraminidase inhibitors. Klumpp, K., Graves, B.J. Curr. Top. Med. Chem (2006) [Pubmed]
  4. Recent progress in the design of small molecule inhibitors of HIV RNase H. Klumpp, K., Mirzadegan, T. Curr. Pharm. Des. (2006) [Pubmed]
  5. Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors. Klumpp, K., Hang, J.Q., Rajendran, S., Yang, Y., Derosier, A., Wong Kai In, P., Overton, H., Parkes, K.E., Cammack, N., Martin, J.A. Nucleic Acids Res. (2003) [Pubmed]
  6. RNA and DNA hydrolysis are catalyzed by the influenza virus endonuclease. Klumpp, K., Doan, L., Roberts, N.A., Handa, B. J. Biol. Chem. (2000) [Pubmed]
  7. Variation in ATP requirement during influenza virus transcription. Klumpp, K., Ford, M.J., Ruigrok, R.W. J. Gen. Virol. (1998) [Pubmed]
 
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