- Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors. Klumpp, K., Hang, J.Q., Rajendran, S., Yang, Y., Derosier, A., Wong Kai In, P., Overton, H., Parkes, K.E., Cammack, N., Martin, J.A. Nucleic Acids Res. (2003)