Lutz F. Tietze
Georg-August-Universität Göttingen
Institut für Organische und Biomolekulare Chemie
Tammannstraße 2
D-37077 Göttingen
Name/email consistency: high
- Synthesis, biological evaluation, and live cell imaging of novel fluorescent duocarmycin analogs. Tietze, L.F., Behrendt, F., Pestel, G.F., Schuberth, I., Mitkovski, M. Chem. Biodivers. (2012)
- First enantioselective total synthesis of (+)-(R)-Pinnatolide using an asymmetric domino allylation reaction. Tietze, L.F., Wolfram, T., Holstein, J.J., Dittrich, B. Org. Lett. (2012)
- Synthesis of tetrasubstituted alkenes through a palladium-catalyzed domino carbopalladation/C-H-activation reaction. Tietze, L.F., Hungerland, T., Düfert, A., Objartel, I., Stalke, D. Chemistry (2012)
- Prodrugs for Targeted Tumor Therapies: Recent Developments in ADEPT, GDEPT and PMT. Tietze, L.F., Schmuck, K. Curr. Pharm. Des. (2011)
- Synthesis and photochemical investigations of tetrasubstituted alkenes as molecular switches-the effect of substituents. Tietze, L.F., Düfert, M.A., Hungerland, T., Oum, K., Lenzer, T. Chemistry (2011)
- Synthesis and biological evaluation of prodrugs based on the natural antibiotic duocarmycin for use in ADEPT and PMT. Tietze, L.F., Schmuck, K., Schuster, H.J., Müller, M., Schuberth, I. Chemistry (2011)
- Glycosidic prodrugs of highly potent bifunctional duocarmycin derivatives for selective treatment of cancer. Tietze, L.F., von Hof, J.M., Müller, M., Krewer, B., Schuberth, I. Angew. Chem. Int. Ed. Engl. (2010)
- The domino multicomponent allylation reaction for the stereoselective synthesis of homoallylic alcohols. Tietze, L.F., Kinzel, T., Brazel, C.C. Acc. Chem. Res. (2009)
- Probing the mechanism of action of potential anticancer agents at a molecular level using electrospray ionisation Fourier transform ion cyclotron resonance mass spectrometry. Tietze, L.F., Krewe, B., Frauendorf, H. Eur. J. Mass. Spectrom. (Chichester,. Eng) (2009)
- Stereoselective allylation of ketones: explanation for the unusual inversion of the induced stereochemistry in the auxiliary-mediated crotylation and pentenylation of butanone by DFT calculations. Tietze, L.F., Kinzel, T., Schmatz, S. Chemistry (2009)
- Novel analogues of CC-1065 and the duocarmycins for the use in targeted tumour therapies. Tietze, L.F., Krewer, B. Anticancer. Agents. Med. Chem (2009)
- Synthesis and biological studies of different duocarmycin based glycosidic prodrugs for their use in the antibody-directed enzyme prodrug therapy. Tietze, L.F., Schuster, H.J., Krewer, B., Schuberth, I. J. Med. Chem. (2009)
- Antibody-directed enzyme prodrug therapy: a promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies. Tietze, L.F., Krewer, B. Chem. Biol. Drug. Des (2009)
- Investigation of the transformations of a novel anti-cancer agent combining HPLC, HPLC-MS and direct ESI-HRMS analyses. Tietze, L.F., Krewer, B., Frauendorf, H. Anal. Bioanal. Chem (2009)
- Asymmetric allylation of methyl ketones by using chiral phenyl carbinols. Tietze, L.F., Kinzel, T., Wolfram, T. Chemistry (2009)
- CD-spectroscopy as a powerful tool for investigating the mode of action of unmodified drugs in live cells. Tietze, L.F., Krewer, B., Major, F., Schuberth, I. J. Am. Chem. Soc. (2009)
- Synthesis of the deoxyaminosugar (+)-D-forosamine via a novel domino-Knoevenagel-hetero-Diels-Alder reaction. Tietze, L.F., Böhnke, N., Dietz, S. Org. Lett. (2009)
- Efficient formal total synthesis of the erythrina alkaloid (+)-erysotramidine, using a domino process. Tietze, L.F., Tölle, N., Kratzert, D., Stalke, D. Org. Lett. (2009)
- Synthesis of chiroptical molecular switches by pd-catalyzed domino reactions. Tietze, L.F., Düfert, A., Lotz, F., Sölter, L., Oum, K., Lenzer, T., Beck, T., Herbst-Irmer, R. J. Am. Chem. Soc. (2009)
- Duocarmycin-based prodrugs for cancer prodrug monotherapy. Tietze, L.F., Schuster, H.J., Schmuck, K., Schuberth, I., Alves, F. Bioorg. Med. Chem. (2008)
- Synthesis of a novel pentagastrin-drug conjugate for a targeted tumor therapy. Tietze, L.F., Panknin, O., Major, F., Krewer, B. Chemistry (2008)
- Enantio- and diastereoselective synthesis of duocarmycine-based prodrugs for a selective treatment of cancer by epoxide opening. Tietze, L.F., Schuster, H.J., Hampel, S.M., Rühl, S., Pfoh, R. Chemistry (2008)
- Efficient synthesis of the structural core of tetracyclines by a palladium-catalyzed domino Tsuji-Trost-Heck-Mizoroki reaction. Tietze, L.F., Redert, T., Bell, H.P., Hellkamp, S., Levy, L.M. Chemistry (2008)
- Stereoselective synthesis of 4-dehydroxydiversonol employing enantioselective palladium-catalysed domino reactions. Tietze, L.F., Spiegl, D.A., Stecker, F., Major, J., Raith, C., Grosse, C. Chemistry (2008)
- Enantioselective total synthesis of the oral contraceptive desogestrel by a double Heck reaction. Tietze, L.F., Krimmelbein, I.K. Chemistry (2008)
- Synthesis of novel structurally simplified estrogen analogues. Tietze, L.F., Vock, C.A., Krimmelbein, I.K., Wiegand, J.M., Nacke, L., Ramachandar, T., Islam, K.M., Gatz, C. Chemistry (2008)
- Total synthesis of polyoxygenated cembrenes. Tietze, L.F., Brazel, C.C., Hölsken, S., Magull, J., Ringe, A. Angew. Chem. Int. Ed. Engl. (2008)
- Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy. Tietze, L.F., von Hof, J.M., Krewer, B., Müller, M., Major, F., Schuster, H.J., Schuberth, I., Alves, F. Chemmedchem (2008)
- Total synthesis of the proposed structure of the anthrapyran metabolite delta-indomycinone. Tietze, L.F., Singidi, R.R., Gericke, K.M. Chemistry (2007)
- Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin. Tietze, L.F., Gericke, K.M., Singidi, R.R., Schuberth, I. Org. Biomol. Chem. (2007)
- Synthesis of novel spinosyn A analogues by Pd-mediated transformations. Tietze, L.F., Brasche, G., Grube, A., Böhnke, N., Stadler, C. Chemistry (2007)
- Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins. Tietze, L.F., Major, F., Schuberth, I., Spiegl, D.A., Krewer, B., Maksimenka, K., Bringmann, G., Magull, J. Chemistry (2007)
- Multiple palladium-catalyzed reactions for the synthesis of analogues of the highly potent insecticide spinosyn A. Tietze, L.F., Brasche, G., Stadler, C., Grube, A., Böhnke, N. Angew. Chem. Int. Ed. Engl. (2006)
- Enantioselective palladium-catalyzed total synthesis of vitamin e by employing a domino Wacker-Heck reaction. Tietze, L.F., Stecker, F., Zinngrebe, J., Sommer, K.M. Chemistry (2006)
- Antitumor agents: development of highly potent glycosidic duocarmycin analogues for selective cancer therapy. Tietze, L.F., Major, F., Schuberth, I. Angew. Chem. Int. Ed. Engl. (2006)
- Investigation of reactivity and selectivity of DNA-alkylating duocarmycin analogues by high-resolution mass spectrometry. Tietze, L.F., Krewer, B., Frauendorf, H., Major, F., Schuberth, I. Angew. Chem. Int. Ed. Engl. (2006)
- Origin of syn/anti diastereoselectivity in aldehyde and ketone crotylation reactions: a combined theoretical and experimental study. Tietze, L.F., Kinzel, T., Schmatz, S. J. Am. Chem. Soc. (2006)
- Enantioselective total synthesis and structure determination of the antiherpetic anthrapyran antibiotic AH-1763 IIa. Tietze, L.F., Gericke, K.M., Singidi, R.R. Angew. Chem. Int. Ed. Engl. (2006)
- Enantioselective total syntheses of the Ipecacuanha alkaloid emetine, the Alangium alkaloid tubulosine and a novel benzoquinolizidine alkaloid by using a domino process. Tietze, L.F., Rackelmann, N., Müller, I. Chemistry (2004)
- Enantioselective palladium-catalyzed transformations. Tietze, L.F., Ila, H., Bell, H.P. Chem. Rev. (2004)
- Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core. Tietze, L.F., Stewart, S.G., Polomska, M.E., Modi, A., Zeeck, A. Chemistry (2004)
- Palladium-catalyzed enantioselective domino reaction for the efficient synthesis of vitamin E. Tietze, L.F., Sommer, K.M., Zinngrebe, J., Stecker, F. Angew. Chem. Int. Ed. Engl. (2004)
- Novel carboranyl C-glycosides for the treatment of cancer by boron neutron capture therapy. Tietze, L.F., Griesbach, U., Schuberth, I., Bothe, U., Marra, A., Dondoni, A. Chemistry (2003)
- Natural product hybrids as new leads for drug discovery. Tietze, L.F., Bell, H.P., Chandrasekhar, S. Angew. Chem. Int. Ed. Engl. (2003)
- Catalyst-controlled stereoselective combinatorial synthesis. Tietze, L.F., Rackelmann, N., Sekar, G. Angew. Chem. Int. Ed. Engl. (2003)
- Enzyme and proton-activated prodrugs for a selective cancer therapy. Tietze, L.F., Feuerstein, T. Curr. Pharm. Des. (2003)
- Efficient synthesis of tetrasubstituted alkenes by allylsilane-terminated domino-Heck double cyclisation. Tietze, L.F., Kahle, K., Raschke, T. Chemistry (2002)
- Novel carboranes with a DNA binding unit for the treatment of cancer by boron neutron capture therapy. Tietze, L.F., Griesbach, U., Bothe, U., Nakamura, H., Yamamoto, Y. Chembiochem (2002)
- Stereoselective synthesis of structurally simplified cephalostatin analogues by multiple Heck reactions and their biological evaluation. Tietze, L.F., Krahnert, W.R. Chemistry (2002)
- Proof of principle in the selective treatment of cancer by antibody-directed enzyme prodrug therapy: the development of a highly potent prodrug. Tietze, L.F., Feuerstein, T., Fecher, A., Haunert, F., Panknin, O., Borchers, U., Schuberth, I., Alves, F. Angew. Chem. Int. Ed. Engl. (2002)
- Synthesis of enantiopure homoallylic ethers by reagent controlled facial selective allylation of chiral ketones. Tietze, L.F., Weigand, B., Völkel, L., Wulff, C., Bittner, C. Chemistry (2001)
- Highly efficient synthesis of linear pyrrole oligomers by twofold Heck reactions. Tietze, L.F., Kettschau, G., Heuschert, U., Nordmann, G. Chemistry (2001)
- Facial-selective allylation of methyl ketones for the asymmetric synthesis of alpha-substituted tertiary homoallylic ethers. Tietze, L.F., Völkel, L., Wulff, C., Weigand, B., Bittner, C., McGrath, P., Johnson, K., Schäfer, M. Chemistry (2001)
- Ortho-carboranyl glycosides for the treatment of cancer by boron neutron capture therapy. Tietze, L.F., Bothe, U., Griesbach, U., Nakaichi, M., Hasegawa, T., Nakamura, H., Yamamoto, Y. Bioorg. Med. Chem. (2001)
- A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs. Tietze, L.F., Lieb, M., Herzig, T., Haunert, F., Schuberth, I. Bioorg. Med. Chem. (2001)
- Carboranyl bisglycosides for the treatment of cancer by boron neutron capture therapy. Tietze, L.F., Bothe, U., Griesbach, U., Nakaichi, M., Hasegawa, T., Nakamura, H., Yamamoto, Y. Chembiochem (2001)
- Highly selective glycosylated prodrugs of cytostatic CC-1065 analogues for antibody-directed enzyme tumor therapy. Tietze, L.F., Herzig, T., Fecher, A., Haunert, F., Schuberth, I. Chembiochem (2001)
- Palladium-catalyzed synthesis of cephalotaxine analogues. Tietze, L.F., Schirok, H., Wöhrmann, M. Chemistry (2000)
- Preparation of a new carboranyl lactoside for the treatment of cancer by boron neutron capture therapy: synthesis and toxicity of fluoro carboranyl glycosides for in vivo 19F-NMR spectroscopy. Tietze, L.F., Bothe, U., Schuberth, I. Chemistry (2000)
- Synthesis of a novel ether-bridged GM3-lactone analogue as a target for an antibody-based cancer therapy. Tietze, L.F., Keim, H., Janssen, C.O., Tappertzhofen, C., Olschimke, J. Chemistry (2000)
- A novel approach in drug discovery: synthesis of estrone--talaromycin natural product hybrids. Tietze, L.F., Schneider, G., Wölfling, J., Fecher, A., Nöbel, T., Petersen, S., Schuberth, I., Wulff, C. Chemistry (2000)
- Domino reactions for library synthesis of small molecules in combinatorial chemistry. Tietze, L.F., Lieb, M.E. Curr. Opin. Chem. Biol (1998)
