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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Rachel F. Tyndale

Department of Pharmacology and Toxicology

The University of Toronto


ON M5S 1A8



Name/email consistency: high



  • Department of Pharmacology and Toxicology, The University of Toronto, Toronto, ON M5S 1A8, Canada. 2011 - 2013
  • Centre for Addiction and Mental Health, Department of Psychiatry, Department of Pharmacology and Toxicology, University of Toronto, Canada. 2003 - 2011
  • Centre for Addictions and Mental Health, Toronto, Ontario, Canada. 1999 - 2002
  • Addiction Research Foundation and Department of Pharmacology, University of Toronto, Canada. 1997 - 1999


  1. Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis. Wassenaar, C.A., Dong, Q., Amos, C.I., Spitz, M.R., Tyndale, R.F. Int. J. Mol. Sci (2013) [Pubmed]
  2. Differential Effects of Nicotine Treatment and Ethanol Self-Administration on CYP2A6, CYP2B6 and Nicotine Pharmacokinetics in African Green Monkeys. Ferguson, C.S., Miksys, S., Palmour, R.M., Tyndale, R.F. J. Pharmacol. Exp. Ther. (2012) [Pubmed]
  3. Independent and Combined Effects of Ethanol Self-Administration and Nicotine Treatment on Hepatic CYP2E1 in African Green Monkeys. Ferguson, C.S., Miksys, S., Palmour, R., Tyndale, R.F. Drug Metab. Dispos. (2011) [Pubmed]
  4. Relationship Between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 Variation and Smoking Behaviors and Lung Cancer Risk. Wassenaar, C.A., Dong, Q., Wei, Q., Amos, C.I., Spitz, M.R., Tyndale, R.F. J. Natl. Cancer Inst. (2011) [Pubmed]
  5. Genetics of alcohol and tobacco use in humans. Tyndale, R.F. Ann. Med. (2003) [Pubmed]
  6. Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Tyndale, R.F., Sellers, E.M. Ther. Drug. Monit (2002) [Pubmed]
  7. Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. Tyndale, R.F., Sellers, E.M. Drug Metab. Dispos. (2001) [Pubmed]
  8. Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan. Tyndale, R.F., Li, Y., Li, N.Y., Messina, E., Miksys, S., Sellers, E.M. Drug Metab. Dispos. (1999) [Pubmed]
  9. A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption. Tyndale, R.F., Pianezza, M.L., Sellers, E.M. Nicotine Tob. Res. (1999) [Pubmed]
  10. Pentobarbital decreases the gamma-aminobutyric acidA receptor subunit gamma-2 long/short mRNA ratio by a mechanism distinct from receptor occupation. Tyndale, R.F., Bhave, S.V., Hoffmann, E., Hoffmann, P.L., Tabakoff, B., Tobin, A.J., Olsen, R.W. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  11. Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence. Tyndale, R.F., Droll, K.P., Sellers, E.M. Pharmacogenetics (1997) [Pubmed]
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