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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Manfred T. Reetz

Department of Synthetic Organic Chemistry

Max-Planck-Institut für Kohlenforschung

Kaiser-Wilhelm-Platz 1

45470 Mülheim an der Ruhr (Germany)


Name/email consistency: high



  • Department of Synthetic Organic Chemistry, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany). 2009 - 2011
  • Max-Planck-Institut für Kohlenforschung, Mülheim, Germany. 1998 - 2009


  1. Manipulating the expression rate and enantioselectivity of an epoxide hydrolase by using directed evolution. Reetz, M.T., Zheng, H. Chembiochem (2011) [Pubmed]
  2. Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: rigorous comparison with traditional methods. Reetz, M.T., Prasad, S., Carballeira, J.D., Gumulya, Y., Bocola, M. J. Am. Chem. Soc. (2010) [Pubmed]
  3. Helical triskelion monophosphites as ligands in asymmetric catalysis. Reetz, M.T., Guo, H., Ma, J.A., Goddard, R., Mynott, R.J. J. Am. Chem. Soc. (2009) [Pubmed]
  4. Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage. Reetz, M.T., Bocola, M., Wang, L.W., Sanchis, J., Cronin, A., Arand, M., Zou, J., Archelas, A., Bottalla, A.L., Naworyta, A., Mowbray, S.L. J. Am. Chem. Soc. (2009) [Pubmed]
  5. Laboratory evolution of robust and enantioselective Baeyer-Villiger monooxygenases for asymmetric catalysis. Reetz, M.T., Wu, S. J. Am. Chem. Soc. (2009) [Pubmed]
  6. Knowledge-guided laboratory evolution of protein thermolability. Reetz, M.T., Soni, P., Fernández, L. Biotechnol. Bioeng. (2009) [Pubmed]
  7. Shedding light on the efficacy of laboratory evolution based on iterative saturation mutagenesis. Reetz, M.T., Kahakeaw, D., Sanchis, J. Mol. Biosyst (2009) [Pubmed]
  8. Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme. Reetz, M.T., Soni, P., Acevedo, J.P., Sanchis, J. Angew. Chem. Int. Ed. Engl. (2009) [Pubmed]
  9. Addressing the numbers problem in directed evolution. Reetz, M.T., Kahakeaw, D., Lohmer, R. Chembiochem (2008) [Pubmed]
  10. A robust protein host for anchoring chelating ligands and organocatalysts. Reetz, M.T., Rentzsch, M., Pletsch, A., Taglieber, A., Hollmann, F., Mondière, R.J., Dickmann, N., Höcker, B., Cerrone, S., Haeger, M.C., Sterner, R. Chembiochem (2008) [Pubmed]
  11. Constructing and analyzing the fitness landscape of an experimental evolutionary process. Reetz, M.T., Sanchis, J. Chembiochem (2008) [Pubmed]
  12. Combinatorial transition-metal catalysis: mixing monodentate ligands to control enantio-, diastereo-, and regioselectivity. Reetz, M.T. Angew. Chem. Int. Ed. Engl. (2008) [Pubmed]
  13. Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions. Reetz, M.T., Wu, S. Chem. Commun. (Camb.) (2008) [Pubmed]
  14. A genetic selection system for evolving enantioselectivity of enzymes. Reetz, M.T., Höbenreich, H., Soni, P., Fernández, L. Chem. Commun. (Camb.) (2008) [Pubmed]
  15. Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes. Reetz, M.T., Carballeira, J.D. Nat. Protoc (2007) [Pubmed]
  16. Learning from directed evolution: Further lessons from theoretical investigations into cooperative mutations in lipase enantioselectivity. Reetz, M.T., Puls, M., Carballeira, J.D., Vogel, A., Jaeger, K.E., Eggert, T., Thiel, W., Bocola, M., Otte, N. Chembiochem (2007) [Pubmed]
  17. Mixtures of chiral phosphorous acid diesters and achiral p ligands in the enantio- and diastereoselective hydrogenation of ketimines. Reetz, M.T., Bondarev, O. Angew. Chem. Int. Ed. Engl. (2007) [Pubmed]
  18. Chiral diphosphites and diphosphoramidites as cheap and efficient ligands in Rh-catalyzed asymmetric olefin hydrogenation. Reetz, M.T., Mehler, G., Bondarev, O. Chem. Commun. (Camb.) (2006) [Pubmed]
  19. Nonlinear effects in Rh-catalyzed asymmetric olefin hydrogenation using mixtures of chiral monodentate P ligands. Reetz, M.T., Fu, Y., Meiswinkel, A. Angew. Chem. Int. Ed. Engl. (2006) [Pubmed]
  20. Iterative saturation mutagenesis on the basis of B factors as a strategy for increasing protein thermostability. Reetz, M.T., Carballeira, J.D., Vogel, A. Angew. Chem. Int. Ed. Engl. (2006) [Pubmed]
  21. High-throughput selection system for assessing the activity of epoxide hydrolases. Reetz, M.T., Wang, L.W. Comb. Chem. High Throughput Screen. (2006) [Pubmed]
  22. Directed evolution of enantioselective enzymes: iterative cycles of CASTing for probing protein-sequence space. Reetz, M.T., Wang, L.W., Bocola, M. Angew. Chem. Int. Ed. Engl. (2006) [Pubmed]
  23. An efficient catalyst system for the asymmetric transfer hydrogenation of ketones: remarkably broad substrate scope. Reetz, M.T., Li, X. J. Am. Chem. Soc. (2006) [Pubmed]
  24. Copper-phthalocyanine conjugates of serum albumins as enantioselective catalysts in Diels-Alder reactions. Reetz, M.T., Jiao, N. Angew. Chem. Int. Ed. Engl. (2006) [Pubmed]
  25. Asymmetric hydrogenation of quinolines catalyzed by iridium complexes of BINOL-derived diphosphonites. Reetz, M.T., Li, X. Chem. Commun. (Camb.) (2006) [Pubmed]
  26. Expanding the substrate scope of enzymes: combining mutations obtained by CASTing. Reetz, M.T., Carballeira, J.D., Peyralans, J., Höbenreich, H., Maichele, A., Vogel, A. Chemistry (2006) [Pubmed]
  27. Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein. Reetz, M.T., Peyralans, J.J., Maichele, A., Fu, Y., Maywald, M. Chem. Commun. (Camb.) (2006) [Pubmed]
  28. Binol-derived monodentate phosphites and phosphoramidites with phosphorus stereogenic centers: novel ligands for transition-metal catalysis. Reetz, M.T., Ma, J.A., Goddard, R. Angew. Chem. Int. Ed. Engl. (2005) [Pubmed]
  29. The influence of mixtures of monodentate achiral ligands on the regioselectivity of transition-metal-catalyzed hydroformylation. Reetz, M.T., Li, X. Angew. Chem. Int. Ed. Engl. (2005) [Pubmed]
  30. Mixtures of configurationally stable and fluxional atropisomeric monodentate P ligands in asymmetric Rh-catalyzed olefin hydrogenation. Reetz, M.T., Li, X. Angew. Chem. Int. Ed. Engl. (2005) [Pubmed]
  31. Expanding the range of substrate acceptance of enzymes: combinatorial active-site saturation test. Reetz, M.T., Bocola, M., Carballeira, J.D., Zha, D., Vogel, A. Angew. Chem. Int. Ed. Engl. (2005) [Pubmed]
  32. Why are BINOL-based monophosphites such efficient ligands in Rh-catalyzed asymmetric olefin hydrogenation?. Reetz, M.T., Meiswinkel, A., Mehler, G., Angermund, K., Graf, M., Thiel, W., Mynott, R., Blackmond, D.G. J. Am. Chem. Soc. (2005) [Pubmed]
  33. Mixtures of monodentate P-ligands as a means to control the diastereoselectivity in Rh-catalyzed hydrogenation of chiral alkenes. Reetz, M.T., Guo, H. Beilstein J. Organic Chemistry (2005) [Pubmed]
  34. Enhancing the enantioselectivity of an epoxide hydrolase by directed evolution. Reetz, M.T., Torre, C., Eipper, A., Lohmer, R., Hermes, M., Brunner, B., Maichele, A., Bocola, M., Arand, M., Cronin, A., Genzel, Y., Archelas, A., Furstoss, R. Org. Lett. (2004) [Pubmed]
  35. Controlling the enantioselectivity of enzymes by directed evolution: practical and theoretical ramifications. Reetz, M.T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  36. A high-throughput NMR-based ee-assay using chemical shift imaging. Reetz, M.T., Tielmann, P., Eipper, A., Ross, A., Schlotterbeck, G. Chem. Commun. (Camb.) (2004) [Pubmed]
  37. Directed evolution as a method to create enantioselective cyclohexanone monooxygenases for catalysis in Baeyer-Villiger reactions. Reetz, M.T., Brunner, B., Schneider, T., Schulz, F., Clouthier, C.M., Kayser, M.M. Angew. Chem. Int. Ed. Engl. (2004) [Pubmed]
  38. Directed evolution of cyclohexanone monooxygenases: enantioselective biocatalysts for the oxidation of prochiral thioethers. Reetz, M.T., Daligault, F., Brunner, B., Hinrichs, H., Deege, A. Angew. Chem. Int. Ed. Engl. (2004) [Pubmed]
  39. Liquid poly(ethylene glycol) and supercritical carbon dioxide as a biphasic solvent system for lipase-catalyzed esterification. Reetz, M.T., Wiesenhöfer, W. Chem. Commun. (Camb.) (2004) [Pubmed]
  40. A new principle in combinatorial asymmetric transition-metal catalysis: mixtures of chiral monodentate P ligands. Reetz, M.T., Sell, T., Meiswinkel, A., Mehler, G. Angew. Chem. Int. Ed. Engl. (2003) [Pubmed]
  41. Enantioselective Rh-catalyzed hydrogenation of vinyl carboxylates with monodentate phosphite ligands. Reetz, M.T., Goossen, L.J., Meiswinkel, A., Paetzold, J., Jensen, J.F. Org. Lett. (2003) [Pubmed]
  42. Lipases as practical biocatalysts. Reetz, M.T. Curr. Opin. Chem. Biol (2002) [Pubmed]
  43. Biocatalysis in ionic liquids: batchwise and continuous flow processes using supercritical carbon dioxide as the mobile phase. Reetz, M.T., Wiesenhöfer, W., Franciò, G., Leitner, W. Chem. Commun. (Camb.) (2002) [Pubmed]
  44. A screening system for enantioselective enzymes based on differential cell growth. Reetz, M.T., Rüggeberg, C.J. Chem. Commun. (Camb.) (2002) [Pubmed]
  45. New methods for the high-throughput screening of enantioselective catalysts and biocatalysts. Reetz, M.T. Angew. Chem. Int. Ed. Engl. (2002) [Pubmed]
  46. Size-selective electrochemical preparation of surfactant-stabilized Pd-, Ni- and Pt/Pd colloids. Reetz, M.T., Winter, M., Breinbauer, R., Thurn-Albrecht, T., Vogel, W. Chemistry (2001) [Pubmed]
  47. Infrared-thermographic screening of the activity and enantioselectivity of enzymes. Reetz, M.T., Hermes, M., Becker, M.H. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  48. BINOL-based diphosphonites as ligands in the asymmetric Rh-catalyzed conjugate addition of arylboronic acids. Reetz, M.T., Moulin, D., Gosberg, A. Org. Lett. (2001) [Pubmed]
  49. Circular dichroism as a detection method in the screening of enantioselective catalysts. Reetz, M.T., Kuhling, K.M., Hinrichs, H., Deege, A. Chirality (2000) [Pubmed]
  50. Overexpression, immobilization and biotechnological application of Pseudomonas lipases. Reetz, M.T., Jaeger, K.E. Chem. Phys. Lipids (1998) [Pubmed]
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