Alireza R. Rezaie
Alireza R. Rezaie
PhD, Department of Biochemistry and Molecular Biology
St. Louis University School of Medicine
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- Contribution of the NH2-terminal EGF-domain of factor IXa to the specificity of intrinsic tenase. Qureshi, S.H., Yang, L., Rezaie, A.R. Thromb. Haemost. (2012)
- The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases. Rezaie, A.R. IUBMB. Life (2011)
- Regulation of the protein C anticoagulant and antiinflammatory pathways. Rezaie, A.R. Curr. Med. Chem. (2010)
- Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z. Rezaie, A.R., Bae, J.S., Manithody, C., Qureshi, S.H., Yang, L. J. Biol. Chem. (2008)
- Heparin chain-length dependence of factor Xa inhibition by antithrombin in plasma. Rezaie, A.R. Thromb. Res. (2007)
- Pentasaccharide enhances the inactivation of factor Xa by antithrombin by promoting the assembly of a Michaelis-type intermediate complex. Demonstration by rapid kinetic, surface plasmon resonance, and competitive binding studies. Rezaie, A.R. Biochemistry (2006)
- Contributions of basic amino acids in the autolysis loop of factor XIa to serpin specificity. Rezaie, A.R., Sun, M.F., Gailani, D. Biochemistry (2006)
- Determinants of specificity of factor xa interaction with its physiological inhibitors. Rezaie, A.R. Mini. Rev. Med. Chem (2006)
- Deletion of the 60-loop provides new insights into the substrate and inhibitor specificity of thrombin. Rezaie, A.R., Yang, L. Thromb. Haemost. (2005)
- Mutagenesis studies toward understanding the mechanism of the cofactor function of thrombomodulin. Rezaie, A.R., Yang, L. Biophys. Chem. (2005)
- Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin. Rezaie, A.R., Yang, L., Manithody, C. Biochemistry (2004)
- Kinetics of factor Xa inhibition by recombinant tick anticoagulant peptide: both active site and exosite interactions are required for a slow- and tight-binding inhibition mechanism. Rezaie, A.R. Biochemistry (2004)
- The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex. Rezaie, A.R., Kittur, F.S. J. Biol. Chem. (2004)
- DX-9065a inhibition of factor Xa and the prothrombinase complex: mechanism of inhibition and comparison with therapeutic heparins. Rezaie, A.R. Thromb. Haemost. (2003)
- Exosite-dependent regulation of the protein C anticoagulant pathway. Rezaie, A.R. Trends Cardiovasc. Med. (2003)
- Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin. Rezaie, A.R., Yang, L. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Partial activation of antithrombin without heparin through deletion of a unique sequence on the reactive site loop of the serpin. Rezaie, A.R. J. Biol. Chem. (2002)
- Insight into the molecular basis of coagulation proteinase specificity by mutagenesis of the serpin antithrombin. Rezaie, A.R. Biochemistry (2002)
- Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C. Rezaie, A.R. J. Biol. Chem. (2001)
- Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex. Rezaie, A.R. Blood (2001)
- Probing the molecular basis of factor Xa specificity by mutagenesis of the serpin, antithrombin. Rezaie, A.R., Yang, L. Biochim. Biophys. Acta (2001)
- Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding. Rezaie, A.R. J. Biol. Chem. (2000)
- Sodium binding site of factor Xa: role of sodium in the prothrombinase complex. Rezaie, A.R., He, X. Biochemistry (2000)
- Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies. Rezaie, A.R., Olson, S.T. Biochemistry (2000)
- Heparin-binding exosite of factor Xa. Rezaie, A.R. Trends Cardiovasc. Med. (2000)