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Chemical Compound Review

CHEMBL114770     1,3-dibutyl-7H-purine-2,6- dione

Synonyms: AG-E-91612, SureCN3186630, ACMC-20a2rg, ANW-54506, CHEBI:288599, ...
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High impact information on NSC515484

  • This hypothesis was supported experimentally by the moderate affinity (Ki 6 microM) of 7-riboside of 1,3-dibutylxanthine, which appears to be a partial agonist at rat A3 receptors [1].
  • 1,3-Dibutylxanthine 7-riboside 5'-N-methylcarboxamide, with a Ki value of 229 nM at A3 receptors, was 160-fold selective for rat A3 vs A1 receptors and > 400-fold selective vs A2a receptors [2].


  1. A binding site model and structure-activity relationships for the rat A3 adenosine receptor. van Galen, P.J., van Bergen, A.H., Gallo-Rodriguez, C., Melman, N., Olah, M.E., IJzerman, A.P., Stiles, G.L., Jacobson, K.A. Mol. Pharmacol. (1994) [Pubmed]
  2. Selective ligands for rat A3 adenosine receptors: structure-activity relationships of 1,3-dialkylxanthine 7-riboside derivatives. Kim, H.O., Ji, X.D., Melman, N., Olah, M.E., Stiles, G.L., Jacobson, K.A. J. Med. Chem. (1994) [Pubmed]
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