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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AGN-PC-0CQXD7     4-hydroxypent-2-enal

Synonyms: AG-E-18660, CTK0I0443, LS-102038, AC1L2U3P, 16931-17-2, ...
 
 
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High impact information on Hydroxypentenal

  • Major products formed in incubations of alpha-acetoxyNPIP for 7-24 h in phosphate buffer (pH 7.0) at 37 degrees C included 4-oxo-2-pentenal (11-21% yield), 4-hydroxypentanal (18-22%), and 5-hydroxypentanal (27-29%) [1].
  • HPE, HHE and HOE induced a clear-cut increase of sister-chromatid exchange (SCE) frequency, while that displayed by cells treated with HNE and HUE was minimal, even if dose-dependent and statistically significant [2].

References

  1. Reaction of alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: oxygen-dependent formation of 4-oxo-2-pentenal and a 1,N2-ethenodeoxyguanosine adduct. Hecht, S.S., Young-Sciame, R., Chung, F.L. Chem. Res. Toxicol. (1992) [Pubmed]
  2. Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes. Brambilla, G., Sciabà, L., Faggin, P., Maura, A., Marinari, U.M., Ferro, M., Esterbauer, H. Mutat. Res. (1986) [Pubmed]
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