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Chemical Compound Review:

OH-PCB-30 4-(2,4,6- trichlorophenyl)phenol

Synonyms: CHEMBL79850, CCRIS 9183, AG-D-95854, SureCN2767670, AC1Q3QMR, ...

Martinez, J.M. et al., Korach, K.S. et al., Tsai, M.L. et al.

Martinez, Stephens, Jones,

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High impact information on C14189

The estrogen receptor bound 4-hydroxy-2',4',6'-trichlorobiphenyl (4H2',4',6'TCB) with the greatest affinity, with the concentration of unlabeled inhibitor yielding half-maximal specific binding relative to estradiol (C50) being approximately 42 compared to estradiol, C50 approximately 1 [1].
Using this model, we compared the effects of 2',4',6'-trichloro-4-biphenylol (OH-PCB-30) and 2',3',4',5'-tetrachloro-4-biphenylol (OH-PCB-61) as prototype estrogenic hydroxylated PCBs (OH-PCBs) because they are reported to exhibit relatively high estrogenic activity both in vivo and in vitro [2].
Increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2',4',6'-trichlorobiphenyl is estrogen receptor mediated [3].

References

Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes. Korach, K.S., Sarver, P., Chae, K., McLachlan, J.A., McKinney, J.D. Mol. Pharmacol. (1988) [Pubmed]
Long-term effects of neonatal exposure to hydroxylated polychlorinated biphenyls in the BALB/cCrgl mouse. Martinez, J.M., Stephens, L.C., Jones, L.A. Environ. Health Perspect. (2005) [Pubmed]
Increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2',4',6'-trichlorobiphenyl is estrogen receptor mediated. Tsai, M.L., Webb, R.C., Loch-Caruso, R. Biol. Reprod. (1997) [Pubmed]

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