Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

ADCIRCA

Synonyms: Acdirca, Tadalafil, Tadanafil, Cialis, TILDENAFIL, ...

Califano, J.A. et al., Giuliano, F. et al.

François Giuliano, Antonio Sanchez-Ramos, Dieter Löchner-Ernst, Giulio Del Popolo, Natalio Cruz, Albert Leriche, Giuseppe Lombardi, Susanne Reichert, Palle Dahl, Albert Elion-Mboussa, Joaquin Casariego,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tadalafil

The 2 most common treatment-emergent adverse events in the tadalafil group compared with placebo were headache (8.5% vs 4.5%) and urinary tract infection (7.7% vs 6.8%) [1].
This study demonstrates that a PDE5 inhibitor, tadalafil, can reverse tumor-specific immune suppression in patients with head and neck cancer, with potential for therapeutic application [2].

References

Efficacy and safety of tadalafil in men with erectile dysfunction following spinal cord injury. Giuliano, F., Sanchez-Ramos, A., Löchner-Ernst, D., Del Popolo, G., Cruz, N., Leriche, A., Lombardi, G., Reichert, S., Dahl, P., Elion-Mboussa, A., Casariego, J. Arch. Neurol. (2007) [Pubmed]
Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma. Califano, J.A., Khan, Z., Noonan, K.A., Rudraraju, L., Zhang, Z., Wang, H., Goodman, S., Gourin, C.G., Ha, P.K., Fakhry, C., Saunders, J., Levine, M., Tang, M., Neuner, G., Richmon, J.D., Blanco, R., Agrawal, N., Koch, W.M., Marur, S., Weed, D.T., Serafini, P., Borrello, I. Clin. Cancer Res. (2015) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share