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Chemical Compound Review

Xalkori     3-[(1R)-1-(2,6-dichloro-3- fluoro...

Synonyms: Crizotinib, QCR-32, PubChem19322, Xalkori (TN), SureCN93829, ...
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Disease relevance of Xalkori

  • Furthermore, HSP90 inhibition, as well as the second-generation ALK inhibitor TAE684, demonstrated activity in newly developed lung adenocarcinoma models driven by crizotinib-insensitive EML4-ALK L1196M or F1174L [1].


  1. Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance. Chen, Z., Akbay, E., Mikse, O., Tupper, T., Cheng, K., Wang, Y., Tan, X., Altabef, A., Woo, S.A., Chen, L., Reibel, J.B., Janne, P.A., Sharpless, N.E., Engelman, J.A., Shapiro, G.I., Kung, A.L., Wong, K.K. Clin. Cancer Res. (2014) [Pubmed]
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