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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

F-Ara-ATP     [[[(2R,3S,4S)-5-(6-amino-2- fluoro-purin-9...

Synonyms: AC1L2QFU, AR-1E1748, AC1Q6S3B, 2-F-Araatp, 2-Fluoro-araatp
 
 
 
 
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High impact information on F-Ara-ATP

  • 2-F-araATP was a potent inhibitor of ribonucleotide reductase; the concentration required for 50% inhibition of ADP reduction (0.3 mM ADP; 5 mM GTP or dGTP) was 1 microM and for CDP reduction (0.15 mM CPD; 5 mM ATP) was 8.5 microM [1].

References

  1. In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells. Tseng, W.C., Derse, D., Cheng, Y.C., Brockman, R.W., Bennett, L.L. Mol. Pharmacol. (1982) [Pubmed]
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